Cities of regional significance
The cities are marked with Latin alphabet lettering.
Category	Second-level subdivision
Location	Ukraine
Created	1932
Abolished	2020
Number	182 (as of 2015)
Government	City council
Subdivisions	Urban districts Councils (municipalities)

A city of regional significance (Ukrainian: місто обласного значення, romanized: misto oblasnoho znachennia) in Ukraine was a type of second-level administrative division or municipality, the other type being raions (districts). In the first-level division of oblasts, they were referred to as cities of oblast significance; in the first-level autonomous republic of Crimea, they were cities of republican significance. The designation was created with the introduction of oblasts in 1932. It was abolished in a 2020 reform that merged raions together and integrated the city municipalities into them.

Such city municipality was complex and usually combined the city proper and adjacent populated places. The city of regional (oblast) significance was governed by a city council known as mis'krada, which was chaired by a mayor. There were instances where a municipality might have included only the city alone (city proper), while in others instances a municipality might have consisted of its own subdivisions such as districts in city, similarly to the cities with special status or even other cities which carried the designation of cities of district significance.

Part of a series on the
Subdivisions of Ukraine
First level
1 autonomous republic 24 oblasts 2 cities with special status
Second level
136 raions
Third level
1469 hromadas

Each region had at least one city of regional significance as its administrative center. A city was usually granted the status for being an economic and cultural center that has a developed industry, utilities, a considerable amount of state provided housing, and a population of over 50,000, and if for further economic and social development of a city it was appropriate to establish a direct management by regional organizations.

In some cases, a city with a population of less than 50,000 could be a city of regional significance if it had industrial, social-cultural, and historical significance, or a propensity for further economical and social development and population increase. These exceptions were usually granted on a decision of the Verkhovna Rada (the Supreme Council of Ukraine).

The city could be divided into districts at the city's authorities' discretion. Along with the raions of a region, the cities of regional significance are the second level of administrative-territorial division of Ukraine. Beside having districts, the city can be divided into various municipal councils (rada, often considered its extended metropolitan area and suburbs) such as smaller city councils, town councils, or rural councils. A city of regional significance can simply be composed of one settlement itself.

In 2012, there were 178 cities of regional significance across the different regions of Ukraine, ranging from the Donetsk Region, which has the highest number of cities at 28. On average there are seven cities in each oblast or Crimea.

Population statistics are from the 2001 Ukrainian Census. An asterisk (*) indicates cities that have district division.

^* - Not shown on map

• Administrative divisions of Ukraine
• City of district significance (Ukraine), similar category for smaller cities
• Consolidated city-county
• List of places named after people (Ukraine)

• Регіони України та їх склад [Regions of Ukraine and their composition]. Official Website of the Parliament of Ukraine (in Ukrainian). Archived from the original on 26 December 2011. Retrieved 25 December 2011.
• "On Procedure of settlement of matters of administrative-territorial structure of the Ukrainian SSR". Verkhovna Rada of Ukraine (in Ukrainian). Retrieved 6 October 2013.