Charles or Charlie Walker may refer to:

• Charles Walker (Fijian politician) (1928–2021), Fijian civil servant, politician and diplomat
• Charles Walker (Georgia politician) (born 1947), American politician
• Charles Walker (British politician) (born 1967), Conservative Party politician
• Charls Walker (1923–2015), under secretary and deputy secretary of the US Treasury
• Charles C. B. Walker (1824–1888), New York U.S. Representative
• Charles Rumford Walker (physician) (1852–1922), New Hampshire State Legislature
• Charles E. Walker (1860–1893), New York State Senate politician
• Charles H. Walker (1828–1877), Wisconsin State Assembly
• Charles Arthur Walker, member of the UK parliament for Wexford Borough

• Charles L. Walker (1832–1904), Latter-day Saint hymn writer
• Charles Curwen Walker (1856–1940), Christadelphian writer and editor
• Charles Coates Walker (1920–2004), American Quaker activist
• Charles Walker (liturgist) (died 1887), liturgist and author
• Charlie Cytron-Walker, American rabbi

• Charles Walker (cricketer, born 1851) (1851–1915), English cricketer
• Charlie Walker (Australian cricketer) (Charles William Walker, 1909–1942), Australian wicket-keeper
• Charlie Walker (English cricketer) (born 1992), English cricketer, plays for Oxford MCCU and for Herefordshire
• Charlie Walker (footballer, born 1911) (1911–1990), English football player
• Charlie Walker (footballer, born 1990), English football player for Aldershot Town
• Charlie Walker (rugby union) (born 1992), English rugby player with Harlequin F.C.
• Chuck Walker (American football) (Charles David Walker, born 1941), American football player
• Chuck Walker (boxer) (born 1957), American boxer

• Charles Vincent Walker (1812–1882), British electrical engineer
• Charles Pyndar Beauchamp Walker (1817–1894), British Army general
• Charles Howard Walker (1857–1936), American architect
• Charles Rumford Walker (1893–1974), American historian
• Charlie Walker (musician) (1926–2008), American country musician
• Charles Walker (checkers player) (born 1934), Mississippi state checkers champion
• Charles Walker (murderer) (1940–1990), convicted murderer and first man to be executed in Illinois after capital punishment was reinstated
• Charles D. Walker (born 1948), American astronaut
• Charles F. Walker, Latin American historian
• Sir Roland Walker (Charles Roland Vincent Walker, born 1970), British Army general