Charles Clarke may refer to:

• Charles Clarke (born 1950), former British Member of Parliament.
• Charles Clarke (judge) (died 1750), English barrister, judge and politician
• Charles Clarke (numismatist) (1719–1780), English numismatist and antiquarian
• Charles Clarke (Canadian politician) (1826–1909), speaker of the Legislative Assembly of Ontario, Canada
• Charles Clarke (botanist), Australian botanist
• Charles Clarke (RAF officer) (1923–2019), British RAF officer and Great Escape lookout
• Charles Baron Clarke (1832–1906), British botanist
• Charles Clarke (antiquary) (died 1840), English antiquary
• Charles E. Clarke (1790–1863), U.S. Representative from New York
• Charles Edwin Clarke (1885–1952), New Zealand entomologist and dentist
• Charles E. J. Clarke (1795–1844), English organist
• Charles Goddard Clarke (1849–1908), Liberal Member of Parliament for Peckham, 1906–1908
• Charles Kirk Clarke (1857–1924), Canadian psychiatrist
• Charlie Clarke (Blue Heelers), fictional character in Australian program, Blue Heelers
• Charlie Clarke (footballer) (1879–1946), Australian rules footballer
• Charles Clarke (cricketer, born 1910) (1910–1997), English cricketer
• Charles Clarke (cricketer, born 1878) (1878–?), Scottish cricketer
• Charles Clarke (Surrey cricketer) (1853–1931), English cricketer
• Charles Cowden Clarke (1787–1877), English author
• Charles G. Clarke (1899–1983), American cinematographer
• Charles Bailey Clarke (1875–1944), mayor of Portland, Maine, 1918–1921
• Charles Clarke (priest) (1871–1947), Anglican priest and author
• C. Allen Clarke (1863–1935), English novelist and journalist
• Sir Charles Clarke, 2nd Baronet (1812–1899)
• Sir Charles Clarke, 3rd Baronet (1839–1932), Quartermaster-General to the Forces
• Charles Henry Douglas Clarke (died 1981), Canadian forester and zoologist

• Charles Clark (disambiguation)
• Charles Clerke (disambiguation)