Cecchini (Italian pronunciation: [tʃekˈkiːni]) is an Italian surname from Umbria, derived from the male given name Cecco (a diminutive of Francesco). Notable people with the surname include:

• Antonio Cecchini (1660–17??), Italian painter of the Baroque period
• Arvedo Cecchini (1924–2011), Italian wrestler
• Dario Cecchini (born 1955), Italian butcher
• Dave Cecchini, American college football player and coach
• Elena Cecchini (born 1992), Italian racing cyclist
• Eleonora Cecchini (born 2003), Sammarinese footballer
• Emanuel Cecchini (born 1996), Argentine footballer
• Garin Cecchini (born 1991), American baseball player in Major League Baseball, brother of Gavin Cecchini
• Gavin Cecchini (born 1993), American baseball player, brother of Garin Cecchini
• Graziano Cecchini (born 1953), Italian artist and activist
• Jessica Cecchini (born 1990), Italian beauty pageant winner
• José Antonio Cecchini (born 1955), retired Spanish wrestler
• Joseph Luke Cecchini (born 1982), Italian skeleton racer
• Sandra Cecchini (born 1965), Italian tennis player
• Libero Cecchini (1919–2020), Italian architect
• Loris Cecchini (born 1969), Italian contemporary artist
• Luca Cecchini (born 1993), Italian footballer
• Luigi Cecchini (born 1944), Italian sports doctor
• Mario Cecchini (1933–2021), Italian Roman Catholic bishop
• Mario Cecchini (businessman), Canadian media and sports executive
• Michele Cecchini (1920–1989), Italian diplomat for the Vatican
• Ramon Cecchini (born 1990), Swiss footballer
• Russell Cecchini, Canadian paralympic athlete
• Silvia Cecchini (born 1994), Italian professional racing cyclist
• Tom Cecchini (born 1944), American football player and coach
• Vasco Cecchini (1932–2023), Italian amateur astronomer

• 13798 Cecchini, an asteroid
• Cecchino (disambiguation)