COMMD1

COMMD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2H2M
Identifiers
Aliases	COMMD1, C2orf5, MURR1, copper metabolism domain containing 1
External IDs	OMIM: 607238; MGI: 109474; HomoloGene: 17604; GeneCards: COMMD1; OMA:COMMD1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	62,147,247 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	22,932,382 bp
RNA expression pattern
	Top expressed in
	Top expressed in
	More reference expression data
	More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
	Sources:Amigo / QuickGO
Orthologs
	150684
	17846
	ENSG00000173163
	ENSMUSG00000051355
	Q8N668
	Q8K4M5
	NM_152516; NM_001321781; NM_001321782; NM_001371765
	NM_144514; NM_001361661
	NP_001308710; NP_001308711; NP_689729; NP_001358694
	NP_653097; NP_001348590
	Wikidata
View/Edit Human	View/Edit Mouse

COMM domain-containing protein 1 is a protein that is encoded by the COMMD1 gene in humans. It was originally regarded as Murr1 before being differentiated and renamed by Dr. Ezra Burstein's Lab^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173163 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051355 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nabetani A, Hatada I, Morisaki H, Oshimura M, Mukai T (Feb 1997). "Mouse U2af1-rs1 is a neomorphic imprinted gene". Mol Cell Biol. 17 (2): 789–98. doi:10.1128/mcb.17.2.789. PMC 231805. PMID 9001233.
^ van De Sluis B, Rothuizen J, Pearson PL, van Oost BA, Wijmenga C (Jan 2002). "Identification of a new copper metabolism gene by positional cloning in a purebred dog population". Hum Mol Genet. 11 (2): 165–73. doi:10.1093/hmg/11.2.165. PMID 11809725.
^ "Entrez Gene: COMMD1 copper metabolism (Murr1) domain containing 1".

External links

Human COMMD1 genome location and COMMD1 gene details page in the UCSC Genome Browser.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Müller T, van de Sluis B, Zhernakova A, et al. (2003). "The canine copper toxicosis gene MURR1 does not cause non-Wilsonian hepatic copper toxicosis". J. Hepatol. 38 (2): 164–8. doi:10.1016/S0168-8278(02)00356-2. PMID 12547404.
Tao TY, Liu F, Klomp L, et al. (2004). "The copper toxicosis gene product Murr1 directly interacts with the Wilson disease protein". J. Biol. Chem. 278 (43): 41593–6. doi:10.1074/jbc.C300391200. PMID 12968035.
Klomp AE, van de Sluis B, Klomp LW, Wijmenga C (2004). "The ubiquitously expressed MURR1 protein is absent in canine copper toxicosis". J. Hepatol. 39 (5): 703–9. doi:10.1016/S0168-8278(03)00380-5. PMID 14568250.
Biasio W, Chang T, McIntosh CJ, McDonald FJ (2004). "Identification of Murr1 as a regulator of the human delta epithelial sodium channel". J. Biol. Chem. 279 (7): 5429–34. doi:10.1074/jbc.M311155200. PMID 14645214.
Ganesh L, Burstein E, Guha-Niyogi A, et al. (2004). "The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes". Nature. 426 (6968): 853–7. doi:10.1038/nature02171. hdl:2027.42/62709. PMID 14685242. S2CID 4344050.
Burstein E, Ganesh L, Dick RD, et al. (2004). "A novel role for XIAP in copper homeostasis through regulation of MURR1". EMBO J. 23 (1): 244–54. doi:10.1038/sj.emboj.7600031. PMC 1271669. PMID 14685266.
Stuehler B, Reichert J, Stremmel W, Schaefer M (2005). "Analysis of the human homologue of the canine copper toxicosis gene MURR1 in Wilson disease patients". J. Mol. Med. 82 (9): 629–34. doi:10.1007/s00109-004-0557-9. PMID 15205742. S2CID 8184776.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Burstein E, Hoberg JE, Wilkinson AS, et al. (2005). "COMMD proteins, a novel family of structural and functional homologs of MURR1". J. Biol. Chem. 280 (23): 22222–32. doi:10.1074/jbc.M501928200. PMID 15799966.
Coronado VA, Bonneville JA, Nazer H, et al. (2006). "COMMD1 (MURR1) as a candidate in patients with copper storage disease of undefined etiology". Clin. Genet. 68 (6): 548–51. doi:10.1111/j.1399-0004.2005.00524.x. PMID 16283886. S2CID 27815621.
Zhang Z, Joh K, Yatsuki H, et al. (2006). "Comparative analyses of genomic imprinting and CpG island-methylation in mouse Murr1 and human MURR1 loci revealed a putative imprinting control region in mice". Gene. 366 (1): 77–86. doi:10.1016/j.gene.2005.08.020. PMID 16305817.
de Bie P, van de Sluis B, Burstein E, et al. (2006). "Characterization of COMMD protein-protein interactions in NF-kappaB signalling". Biochem. J. 398 (1): 63–71. doi:10.1042/BJ20051664. PMC 1525016. PMID 16573520.
Sommerhalter M, Zhang Y, Rosenzweig AC (2007). "Solution structure of the COMMD1 N-terminal domain". J. Mol. Biol. 365 (3): 715–21. doi:10.1016/j.jmb.2006.10.030. PMC 2706016. PMID 17097678.
Maine GN, Mao X, Komarck CM, Burstein E (2007). "COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase". EMBO J. 26 (2): 436–47. doi:10.1038/sj.emboj.7601489. PMC 1783443. PMID 17183367.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173163 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051355 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9001233-5] Nabetani A, Hatada I, Morisaki H, Oshimura M, Mukai T (Feb 1997). "Mouse U2af1-rs1 is a neomorphic imprinted gene". Mol Cell Biol. 17 (2): 789–98. doi:10.1128/mcb.17.2.789. PMC 231805. PMID 9001233.

[pmid11809725-6] van De Sluis B, Rothuizen J, Pearson PL, van Oost BA, Wijmenga C (Jan 2002). "Identification of a new copper metabolism gene by positional cloning in a purebred dog population". Hum Mol Genet. 11 (2): 165–73. doi:10.1093/hmg/11.2.165. PMID 11809725.

[entrez-7] "Entrez Gene: COMMD1 copper metabolism (Murr1) domain containing 1".

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[4]

[5]

[6]

[7]

Fahrer / Team für die Suche eingeben:

Fahrer / Team für die Suche eingeben:

Langbahn Team – Weltmeisterschaft

COMMD1

References

External links

Further reading