CHM may refer to:

• CHM, abbreviation for Clearing House Mechanism under the Convention on Biological Diversity
• CHM, a human gene that encodes Rab escort protein 1
• Choroideremia, a retinal disease caused by mutations in the CHM gene
• ChM, advanced qualification in surgery, (Magister Chirurgiae). See Master of Surgery
• Chinese herbal medicine abbreviation, see Chinese herbology
• Christian Healthcare Ministries, a Health care sharing ministry
• Children's Hospital of Michigan, in Detroit, Michigan
• Commission on Human Medicines, a committee of the UK's Medicines and Healthcare Products Regulatory Agency
• Michigan State University College of Human Medicine

• ".chm", filename extension for ChemDraw Chemical Structure files
• ".chm", filename extension for Microsoft Compiled HTML Help files

• College Hockey Mid-America, an American Collegiate Hockey Association
• Congregation of the Humility of Mary, a congregation of religious sisters in the Catholic Church
• Conservative Holiness Movement, a theologically conservative group of Methodist, Quaker, Anabaptist and Restorationist denominations

• Cultural heritage management, the vocation and practice of managing cultural heritage
• Chicago History Museum, founded in 1856 to study and interpret Chicago's history
• Colorado History Museum, a museum in Denver on the history of the state of Colorado
• Computer History Museum, established in 1996 in Mountain View, California

• CHM, IATA code for Tnte. FAP Jaime Montreuil Morales Airport, Peru
• CHM, Amtrak station code for Illinois Terminal in Champaign, Illinois
• Chatham railway station, Melbourne

• chm, ISO 639 code for Mari language
• CHM, abbreviation for contraharmonic mean
• Ch.M., postnominal for Magistral Chaplain, used by the Sovereign Military Order of Malta
• ChM, the label of the Chelyabinsk meteor
• Channel M (Southeast Asia), a cable TV channel in Southeast Asia