CFU-Meg

CFU-Meg
CFU-Meg
Details
Gives rise to	Megakaryocytes and those to platelets
Location	Bone marrow
Function	Colony forming unit
Identifiers
TH	H2.00.04.3.02013
	Anatomical terms of microanatomy [edit on Wikidata]

CFU-Meg is a colony forming unit. Haematopoiesis in the bone marrow starts off from a haematopoietic stem cell (HSC) and this can differentiate into the myeloid and lymphoid cell lineages. In order to eventually produce a megakaryocyte, the haematopoietic stem cell must generate myeloid cells, so it becomes a common myeloid progenitor, CFU-GEMM. This in turn develops into CFU-Meg, which is the colony forming unit that leads to the production of megakaryocytes.^[1]^[2]^[3]

Some sources prefer the term "CFU-Mega".^[4]

References

^ Kimura H, Ohkoshi T, Matsuda S, Uchida T, Kariyone S (1988). "Megakaryocytopoiesis in polycythemia vera: characterization by megakaryocytic progenitors (CFU-Meg) in vitro and quantitation of marrow megakaryocytes". Acta Haematol. 79 (1): 1–6. doi:10.1159/000205681. PMID 3124455.
^ Kimura H, Ishibashi T, Sato T, Matsuda S, Uchida T, Kariyone S (January 1987). "Megakaryocytic colony formation (CFU-Meg) in essential thrombocythemia: quantitative and qualitative abnormalities of bone marrow CFU-Meg". Am. J. Hematol. 24 (1): 23–30. doi:10.1002/ajh.2830240104. PMID 3799592. S2CID 20893511.
^ Gallicchio VS, Hughes NK, Hulette BC, Noblitt L (December 1991). "Effect of interleukin-1, GM-CSF, erythropoietin, and lithium on the toxicity associated with 3'-azido-3'-deoxythymidine (AZT) in vitro on hematopoietic progenitors (CFU-GM, CFU-MEG, and BFU-E) using murine retrovirus-infected hematopoietic cells". J. Leukoc. Biol. 50 (6): 580–6. doi:10.1002/jlb.50.6.580. PMID 1940611. S2CID 9700067.^{[permanent dead link‍]}
^ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease. St. Louis, Mo: Elsevier Saunders. p. 621. ISBN 0-7216-0187-1.