CFR may refer to:

• 23S rRNA (adenine2503-C2,C8)-dimethyltransferase, an enzyme
• 23S rRNA (adenine2503-C2)-methyltransferase, an enzyme

• Căile Ferate Române, the Romanian state railway
• Canadian Finals Rodeo
• Centre for Foreign Relations, Tanzania
• CFR Cluj, Romanian football club
• CFFR, a Canadian radio station once branded as "66 CFR"
• Chess Federation of Russia, the governing body for chess in Russia
• Council on Foreign Relations, U.S. foreign policy think tank
• Franciscan Friars of the Renewal, a religious institute in the Catholic Church commonly abbreviated "C.F.R."

• Caen – Carpiquet Airport in northern France

• Charter of Fundamental Rights, a charter of political, social and economic rights for European Union (EU) citizens
• Code of Federal Regulations of the United States

• Certified first responder
• Commander of the Order of the Federal Republic, Nigerian order of merit

• Case fatality rate, term for proportion of people dying of a disease
• Compact fusion reactor, a proposed nuclear fusion reactor project
• Coronary flow reserve, a diagnostic cardiac measurement
• Cost and Freight, word used in international commerce
• Cross-Functional Requirements, another name for non-functional requirements or the "ilities" in software systems requirements and design
• Chinese Folk Religion, the millennia-old indigenous beliefs and folklore of China that later morphed into Taoism, Confucianism, and Chinese Buddhism