Protein-coding gene in humans
Centromere protein I is a protein that in humans is encoded by the CENPI gene .[ 5] [ 6]
Function The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone . This gene is also a potential candidate for human X-linked disorders of gonadal development and gametogenesis .[ 6] transcription factor E2F .[ 7] breast cancer and this has been shown to cause chromosome instability in breast cancer cells.[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000102384 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031262 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nature Cell Biology . 8 (5): 446–57. doi :10.1038/ncb1396 . PMID 16622420 . S2CID 26974412 . ^ a b "Entrez Gene: CENPI centromere protein I" .^ a b Thangavelu PU, Lin CY, Vaidyanathan S, Nguyen TH, Dray E, Duijf PH (September 2017). "CENPI promotes chromosome instability and predicts poor prognosis in estrogen receptor-positive breast cancer" . Oncotarget . 8 (37): 62167–62182. doi :10.18632/oncotarget.19131 . PMC 5617495 PMID 28977935 .
Further reading
Izuta H, Ikeno M, Suzuki N, Tomonaga T, Nozaki N, Obuse C, Kisu Y, Goshima N, Nomura F, Nomura N, Yoda K (June 2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells" . Genes to Cells . 11 (6): 673–84. doi :10.1111/j.1365-2443.2006.00969.x PMID 16716197 . Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nature Cell Biology . 8 (5): 458–69. doi :10.1038/ncb1397 . PMID 16622419 . S2CID 205286556 . Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle" . Proceedings of the National Academy of Sciences of the United States of America . 103 (14): 5391–6. Bibcode :2006PNAS..103.5391N . doi :10.1073/pnas.0507066103 PMC 1459365 PMID 16565220 . Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (February 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase" . Genes to Cells . 9 (2): 105–20. doi :10.1111/j.1365-2443.2004.00705.x PMID 15009096 . S2CID 21813024 . Liu ST, Hittle JC, Jablonski SA, Campbell MS, Yoda K, Yen TJ (April 2003). "Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis". Nature Cell Biology . 5 (4): 341–5. doi :10.1038/ncb953 . PMID 12640463 . S2CID 33165992 . Roberts RG, Kendall E, Vetrie D, Bobrow M (October 1996). "Sequence and chromosomal location of a human homologue of LRPR1, an FSH primary response gene". Genomics . 37 (1): 122–4. doi :10.1006/geno.1996.0528 . PMID 8921378 . Slegtenhorst-Eegdeman KE, Post M, Baarends WM, Themmen AP, Grootegoed JA (February 1995). "Regulation of gene expression in Sertoli cells by follicle-stimulating hormone (FSH): cloning and characterization of LRPR1, a primary response gene encoding a leucine-rich protein" . Molecular and Cellular Endocrinology . 108 (1–2): 115–24. doi :10.1016/0303-7207(94)03468-9 . hdl :1765/64471 PMID 7758824 . S2CID 11122437 . Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR, Nagle JW, Fields C, Venter JC (February 1992). "Sequence identification of 2,375 human brain genes". Nature . 355 (6361): 632–4. Bibcode :1992Natur.355..632A . doi :10.1038/355632a0 . PMID 1538749 . S2CID 4234345 .
External links
Basic Types Processes Structures
See also
