Human protein
CD6 (C luster of D ifferentiation 6) is a human protein encoded by the CD6 gene .[ 5] [ 6]
Function This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule . The gene product is important for continuation of T cell activation .[ 5]
Clinical significance Certain alleles of this gene may be associated with susceptibility to multiple sclerosis .[ 7] [ 8]
See also
References
^ a b c GRCh38: Ensembl release 89: ENSG00000013725 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024670 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: CD6 CD6 molecule" .^ Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U (1995). "Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand" . J. Exp. Med . 181 (6): 2213–20. doi :10.1084/jem.181.6.2213 . PMC 2192054 PMID 7760007 . ^ De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S, Baranzini SE, McCauley JL, Pericak-Vance MA, Haines JL, Gibson RA, Naeglin Y, Uitdehaag B, Matthews PM, Kappos L, Polman C, McArdle WL, Strachan DP, Evans D, Cross AH, Daly MJ, Compston A, Sawcer SJ, Weiner HL, Hauser SL, Hafler DA, Oksenberg JR (2009). "Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci" . Nat. Genet . 41 (7): 776–82. doi :10.1038/ng.401 . PMC 2757648 PMID 19525953 . ^ Kofler DM, Severson CA, Mousissian N, De Jager PL, Hafler DA (2011). "The CD6 multiple sclerosis susceptibility allele is associated with alterations in CD4+ T cell proliferation" . J. Immunol . 187 (6): 3286–91. doi :10.4049/jimmunol.1100626 PMID 21849685 .
Further reading
Aruffo A, Melnick MB, Linsley PS, Seed B (1991). "The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins" . J. Exp. Med . 174 (4): 949–52. doi :10.1084/jem.174.4.949 . PMC 2118957 PMID 1919444 . Swack JA, Mier JW, Romain PL, Hull SR, Rudd CE (1991). "Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule" . J. Biol. Chem . 266 (11): 7137–43. doi :10.1016/S0021-9258(20)89621-5 PMID 2016320 . Tsuge I, Utsumi KR, Ueda R, Takamoto S, Takahashi T (1985). "Assignment of gene coding human T-cell differentiation antigen, Tp120, to chromosome 11". Somat. Cell Mol. Genet . 11 (3): 217–22. doi :10.1007/BF01534678 . PMID 3923629 . S2CID 39343360 . Whitney GS, Starling GC, Bowen MA, Modrell B, Siadak AW, Aruffo A (1995). "The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule binding site" . J. Biol. Chem . 270 (31): 18187–90. doi :10.1074/jbc.270.31.18187 PMID 7543097 . Robinson WH, Neuman de Vegvar HE, Prohaska SS, Rhee JW, Parnes JR (1995). "Human CD6 possesses a large, alternatively spliced cytoplasmic domain". Eur. J. Immunol . 25 (10): 2765–9. doi :10.1002/eji.1830251008 . PMID 7589069 . S2CID 8996113 . Wee S, Schieven GL, Kirihara JM, Tsu TT, Ledbetter JA, Aruffo A (1993). "Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors" . J. Exp. Med . 177 (1): 219–23. doi :10.1084/jem.177.1.219 . PMC 2190871 PMID 7678115 . Bowen MA, Whitney GS, Neubauer M, Starling GC, Palmer D, Zhang J, Nowak NJ, Shows TB, Aruffo A (1997). "Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms" . J. Immunol . 158 (3): 1149–56. doi :10.4049/jimmunol.158.3.1149 PMID 9013954 . S2CID 24196035 . Kobarg J, Whitney GS, Palmer D, Aruffo A, Bowen MA (1998). "Analysis of the tyrosine phosphorylation and calcium fluxing of human CD6 isoforms with different cytoplasmatic domains". Eur. J. Immunol . 27 (11): 2971–80. doi :10.1002/eji.1830271133 . PMID 9394826 . S2CID 20897222 . Singer NG, Mitra R, Lialios F, Richardson BC, Marks RM, Pesando JM, Fox DA, Nickoloff BJ (1998). "CD6 dependent interactions of T cells and keratinocytes: functional evidence for a second CD6 ligand on gamma-interferon activated keratinocytes". Immunol. Lett . 58 (1): 9–14. doi :10.1016/S0165-2478(97)02707-7 . PMID 9436462 . Gimferrer I, Farnós M, Calvo M, Mittelbrunn M, Enrich C, Sánchez-Madrid F, Vives J, Lozano F (2003). "The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells" . J. Biol. Chem . 278 (10): 8564–71. doi :10.1074/jbc.M209591200 PMID 12473675 . Shin BK, Wang H, Yim AM, Le Naour F, Brichory F, Jang JH, Zhao R, Puravs E, Tra J, Michael CW, Misek DE, Hanash SM (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function" . J. Biol. Chem . 278 (9): 7607–16. doi :10.1074/jbc.M210455200 PMID 12493773 . Gimferrer I, Ibáñez A, Farnós M, Sarrias MR, Fenutría R, Roselló S, Zimmermann P, David G, Vives J, Serra-Pagès C, Lozano F (2005). "The lymphocyte receptor CD6 interacts with syntenin-1, a scaffolding protein containing PDZ domains" . J. Immunol . 175 (3): 1406–14. doi :10.4049/jimmunol.175.3.1406 PMID 16034076 . Kato Y, Tanaka Y, Hayashi M, Okawa K, Minato N (2006). "Involvement of CD166 in the activation of human gamma delta T cells by tumor cells sensitized with nonpeptide antigens" . J. Immunol . 177 (2): 877–84. doi :10.4049/jimmunol.177.2.877 PMID 16818742 . Ibáñez A, Sarrias MR, Farnós M, Gimferrer I, Serra-Pagès C, Vives J, Lozano F (2006). "Mitogen-activated protein kinase pathway activation by the CD6 lymphocyte surface receptor" . J. Immunol . 177 (2): 1152–9. doi :10.4049/jimmunol.177.2.1152 PMID 16818773 . Hassan NJ, Simmonds SJ, Clarkson NG, Hanrahan S, Puklavec MJ, Bomb M, Barclay AN, Brown MH (2006). "CD6 Regulates T-Cell Responses through Activation-Dependent Recruitment of the Positive Regulator SLP-76" . Mol. Cell. Biol . 26 (17): 6727–38. doi :10.1128/MCB.00688-06 . PMC 1592849 PMID 16914752 . Castro MA, Oliveira MI, Nunes RJ, Fabre S, Barbosa R, Peixoto A, Brown MH, Parnes JR, Bismuth G, Moreira A, Rocha B, Carmo AM (2007). "Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse" . J. Immunol . 178 (7): 4351–61. doi :10.4049/jimmunol.178.7.4351 PMID 17371992 . Sarrias MR, Farnós M, Mota R, Sánchez-Barbero F, Ibáñez A, Gimferrer I, Vera J, Fenutría R, Casals C, Yélamos J, Lozano F (2007). "CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock" . Proc. Natl. Acad. Sci. U.S.A . 104 (28): 11724–9. Bibcode :2007PNAS..10411724S . doi :10.1073/pnas.0702815104 PMC 1913855 PMID 17601777 .
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This article incorporates text from the United States National Library of Medicine , which is in the public domain .
