A brain is a biological organ.

Brain(s) or The Brain may also refer to:

• The Brain (1962 film), directed by Freddie Francis
• The Brain (1969 film), a French comedy film directed by Gérard Oury
• The Brain (1988 film), a Canadian science fiction horror film

• Brain Records, a German record label prominent in the 1970s
• The Brains, an Atlanta band who did the original version of the song "Money Changes Everything"
• Brain (EP), a 1993 split EP with the bands Klinik and Paracont
• Brain (album), a 2004 album from Hiromi Uehara
• "Brain", a song on the 2006 album The Zico Chain by Zico Chain
• "Brain", a song on the 2001 album In Search of... by N.E.R.D.
• "Brain", a song by Yang Yo-seob
• "Brains", song by the band Lower Dens from their album Nootropics
• "Brains", song by the band The Presets from their album Hi Viz
• "Brains!", 2002 song by the musician Voltaire, from Boo Hoo
• "Brains", a track from the soundtrack of the 2014 Indian film Jigarthanda

• The Brain with David Eagleman, a 2015 American television series
• Brain (TV series), a 2011 South Korean KBS medical drama series
• The Brain (game show), a 2014 Chinese series
• "Brains", a 2011 Voltron Force episode

• The Brain (Bell comics), created by Leo Bachle for Bell Features
• Brains (Thunderbirds), in the 1960s British series
• Brain (DC Comics), created for DC Comics
• Brain, a mouse in the cartoon series Pinky and the Brain and Animaniacs
• Brain, cat in the Top Cat animated series and movie, see list of Top Cat characters
• Brain, a dog in the cartoon series Inspector Gadget
• The Brain, bear in the television series Athur, see list of Arthur characters
• "Brain", a character in the film Igor
• The B.R.A.I.N. machine, from the film 9
• Dr. Brain, in the 1990s Dr. Brain series of educational games
• Brain, a character played by American rapper Lil Dicky on his EP I'm Brain

• Brain (novel), by Robin Cook

• Brain (surname)
• "The Brain", nickname of Bobby Heenan (1944-2017), wrestler and manager
• "The Brain", nickname of Arnold Rothstein (1882-1928), gangster and gambler
• Bryan Mantia (born 1963), American rock drummer nicknamed "Brain"
• Zelda the Brain, a female professional wrestler from the Gorgeous Ladies of Wrestling
• M.C. Brains (born 1974), American rapper

• Brain, Côte-d'Or, France, a commune
• Brains, Loire-Atlantique, France, a commune
• River Brain, Essex, England

• Brain (journal), a peer-reviewed scientific journal of neurology founded in 1878
• Brain (computer virus), first released in 1986, considered to be the first computer virus for MS-DOS
• TheBrain, mind mapping and personal knowledge base software from TheBrain Technologies

• Baron Brain, a noble title
• The Brain (club), in London
• Brains Brewery, a regional brewery in Wales
• The Brain Prize, an international research award
• Brain, slang for oral sex

• BRAIN Initiative, a 2013 American initiative to map the human brain
• CBI 5: The Brain, a 2022 Indian film
• various Irish kings:
  • Cellach mac Brain (died 834), King of Leinster
  • Cennselach mac Brain (died 770), a king of the Uí Cheinnselaig of South Leinster
  • Máel Muad mac Brain (died 978), King of Munster
  • Muiredach mac Brain (died 885), King of Leinster
  • Muiredach mac Brain (died 818), King of Leinster
  • Ruarc mac Brain (died 862), King of Leinster
• Brane (disambiguation)
• Brayne, a list of people with the surname