Bottoms Up may refer to:

• Bottoms Up (Illinois Jacquet album), 1968
• Bottoms Up (Obie Trice album), 2012
• Bottoms Up!, a 1959 album by jazz group The Three Sounds
• "Bottoms Up" (Brantley Gilbert song), 2013
• "Bottoms Up" (Middle of the Road song), song by Scottish band Middle of the Road, 1972
• "Bottoms Up" (Nickelback song) from Nickelback's album Here and Now
• "Bottoms Up" (Trey Songz song), 2010
• "U Was at the Club (Bottoms Up)", song by The BoyBoy West Coast
• "Bottoms Up", a song by Keke Palmer from her debut album So Uncool
• "Bottoms Up!", track four on Van Halen's album Van Halen II

• Bottoms Up (1934 film), a 1934 musical comedy film
• Bottoms Up (1960 film), starring Jimmy Edwards
• Bottoms Up (2006 film), a film starring Paris Hilton
• 'S Up, the fifth episode of the first series of British sitcom Bottom
• Bottoms Up (Entourage), an episode of the TV series Entourage

• Bottoms Up Club, a bar in Hong Kong
• "Bottoms Up" Shot Cup, risqué ceramic cup featuring a naked girl draped over the bottom

• Bottom-up (disambiguation)
• Top-down (disambiguation)