Belcastro is an Italian surname. Notable people with the surname include:

• James Belcastro (1895–1945), American mobster
• Lisa Belcastro (born 1988), American politician
• Luca Belcastro (born 1964), Italian classical composer
• Marie Belcastro (1920–2015), American murder victim
• Pete Belcastro, American television and radio personality
• Sarah-Marie Belcastro (born 1970), American mathematician known for mathematical knitting