Barbero is an Italian and Spanish surname. Notable people with the surname include:

• Aldo Barbero (1938–2013), Argentine actor
• Alessandro Barbero (born 1959), Italian historian
• Andrés Barbero (1877–1951), Paraguayan physician and philanthropist
• Gerardo Barbero (1961–2001), Argentine chess grandmaster
• Giuseppe Barbero (born 1927), Italian economist
• John Barbero (1945–2010), American public address announcer
• Lori Barbero (born 1961), American rock drummer

• Barbera (disambiguation)
• Barberi, a surname