Protein-coding gene in the species Homo sapiens
Baculoviral IAP repeat-containing protein 6 is a protein that in humans is encoded by the BIRC6 gene .[ 5] [ 6]
Function This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.[ 6]
Interactions BIRC6 has been shown to interact with KIF23 .[ 7]
Diseases BIRC6 is implicated in leukemia, melanoma, breast cancer, lung cancer, colorectal cancer, and other cancers[ 8] Atlas of Genetics and Cytogenetics in Oncology and Haematology [ 9]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000115760 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024073 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Chen Z, Naito M, Hori S, Mashima T, Yamori T, Tsuruo T (Dec 1999). "A human IAP-family gene, apollon, expressed in human brain cancer cells". Biochem Biophys Res Commun . 264 (3): 847– 54. doi :10.1006/bbrc.1999.1585 . PMID 10544019 . ^ a b "Entrez Gene: BIRC6 baculoviral IAP repeat-containing 6 (apollon)" .^ Pohl C, Jentsch S (Mar 2008). "Final stages of cytokinesis and midbody ring formation are controlled by BRUCE" . Cell . 132 (5): 832– 45. doi :10.1016/j.cell.2008.01.012 PMID 18329369 . S2CID 12192141 . ^ "BIRC6 (Baculoviral IAP repeat-containing 6)" . atlasgeneticsoncology.org .^ "Atlas of Genetics and Cytogenetics in Oncology and Haematology" . atlasgeneticsoncology.org .
External links Human BIRC6 BIRC6 UCSC Genome Browser .
PDBe-KB provides an overview of all the structure information available in the PDB for Human Baculoviral IAP repeat-containing protein 6
Further reading
Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones" . DNA Res . 9 (3): 99– 106. doi :10.1093/dnares/9.3.99 PMID 12168954 . Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF) . Nature . 377 (6547 Suppl): 3– 174. PMID 7566098 . Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791– 806. doi :10.1101/gr.6.9.791 PMID 8889548 . Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 6 (5): 337– 45. doi :10.1093/dnares/6.5.337 PMID 10574462 . Qiu XB, Markant SL, Yuan J, Goldberg AL (2005). "Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis" . EMBO J . 23 (4): 800– 10. doi :10.1038/sj.emboj.7600075 . PMC 380992 PMID 14765125 . Bartke T, Pohl C, Pyrowolakis G, Jentsch S (2005). "Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase" . Mol. Cell . 14 (6): 801– 11. doi :10.1016/j.molcel.2004.05.018 PMID 15200957 . Hao Y, Sekine K, Kawabata A, Nakamura H, Ishioka T, Ohata H, Katayama R, Hashimoto C, Zhang X, Noda T, Tsuruo T, Naito M (2004). "Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function". Nat. Cell Biol . 6 (9): 849– 60. doi :10.1038/ncb1159 . PMID 15300255 . S2CID 22850781 . Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8" . Mol. Cell. Biol . 24 (17): 7748– 57. doi :10.1128/MCB.24.17.7748-7757.2004 . PMC 506982 PMID 15314180 . Qiu XB, Goldberg AL (2005). "The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9" . J. Biol. Chem . 280 (1): 174– 82. doi :10.1074/jbc.M411430200 PMID 15507451 .
