Protein-coding gene in the species Homo sapiens
Transcription regulator protein BACH2 (broad complex-tramtrack-bric a brac and Cap'n'collar homology 2) is a protein that in humans is encoded by the BACH2 gene .[ 5] [ 6] [ 7] BTB/POZ domain at its N-terminus which forms a disulphide-linked dimer [ 8] bZip_Maf domain at the C-terminus.
References
^ a b c GRCh38: Ensembl release 89: ENSG00000112182 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040270 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Sasaki S, Ito E, Toki T, Maekawa T, Kanezaki R, Umenai T, Muto A, Nagai H, Kinoshita T, Yamamoto M, Inazawa J, Taketo MM, Nakahata T, Igarashi K, Yokoyama M (August 2000). "Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15" . Oncogene . 19 (33): 3739–49. doi :10.1038/sj.onc.1203716 PMID 10949928 . ^ Kamio T, Toki T, Kanezaki R, Sasaki S, Tandai S, Terui K, Ikebe D, Igarashi K, Ito E (November 2003). "B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs" . Blood . 102 (9): 3317–22. doi :10.1182/blood-2002-12-3656 PMID 12829606 . ^ "Entrez Gene: BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2" .^ Rosbrook GO, Stead MA, Carr SB, Wright SC (January 2012). "The structure of the Bach2 POZ-domain dimer reveals an intersubunit disulfide bond" (PDF) . Acta Crystallographica Section D . 68 (Pt 1): 26–34. Bibcode :2012AcCrD..68...26R . doi :10.1107/S0907444911048335 . PMID 22194330 .
Further reading
Oyake T, Itoh K, Motohashi H, Hayashi N, Hoshino H, Nishizawa M, Yamamoto M, Igarashi K (November 1996). "Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site" . Molecular and Cellular Biology . 16 (11): 6083–95. doi :10.1128/mcb.16.11.6083 . PMC 231611 PMID 8887638 . Kobayashi A, Yamagiwa H, Hoshino H, Muto A, Sato K, Morita M, Hayashi N, Yamamoto M, Igarashi K (March 2000). "A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain" . Molecular and Cellular Biology . 20 (5): 1733–46. doi :10.1128/MCB.20.5.1733-1746.2000 . PMC 85356 PMID 10669750 . Hoshino H, Kobayashi A, Yoshida M, Kudo N, Oyake T, Motohashi H, Hayashi N, Yamamoto M, Igarashi K (May 2000). "Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element" . The Journal of Biological Chemistry . 275 (20): 15370–6. doi :10.1074/jbc.275.20.15370 PMID 10809773 . Vieira SA, Deininger MW, Sorour A, Sinclair P, Foroni L, Goldman JM, Melo JV (December 2001). "Transcription factor BACH2 is transcriptionally regulated by the BCR/ABL oncogene". Genes, Chromosomes & Cancer . 32 (4): 353–63. doi :10.1002/gcc.1200 . PMID 11746976 . S2CID 21020332 . Muto A, Tashiro S, Tsuchiya H, Kume A, Kanno M, Ito E, Yamamoto M, Igarashi K (June 2002). "Activation of Maf/AP-1 repressor Bach2 by oxidative stress promotes apoptosis and its interaction with promyelocytic leukemia nuclear bodies" . The Journal of Biological Chemistry . 277 (23): 20724–33. doi :10.1074/jbc.M112003200 PMID 11923289 . Takakuwa T, Luo WJ, Ham MF, Sakane-Ishikawa F, Wada N, Aozasa K (March 2004). "Integration of Epstein-Barr virus into chromosome 6q15 of Burkitt lymphoma cell line (Raji) induces loss of BACH2 expression" . The American Journal of Pathology . 164 (3): 967–74. doi :10.1016/S0002-9440(10)63184-7 . PMC 1614712 PMID 14982850 . Tashiro S, Muto A, Tanimoto K, Tsuchiya H, Suzuki H, Hoshino H, Yoshida M, Walter J, Igarashi K (April 2004). "Repression of PML nuclear body-associated transcription by oxidative stress-activated Bach2" . Molecular and Cellular Biology . 24 (8): 3473–84. doi :10.1128/MCB.24.8.3473-3484.2004 . PMC 381671 PMID 15060166 . Motamed-Khorasani A, Jurisica I, Letarte M, Shaw PA, Parkes RK, Zhang X, Evangelou A, Rosen B, Murphy KJ, Brown TJ (January 2007). "Differentially androgen-modulated genes in ovarian epithelial cells from BRCA mutation carriers and control patients predict ovarian cancer survival and disease progression". Oncogene . 26 (2): 198–214. doi :10.1038/sj.onc.1209773 . PMID 16832351 . S2CID 23262017 . Yoshida C, Yoshida F, Sears DE, Hart SM, Ikebe D, Muto A, Basu S, Igarashi K, Melo JV (February 2007). "Bcr-Abl signaling through the PI-3/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1" . Blood . 109 (3): 1211–9. doi :10.1182/blood-2005-12-040972 PMID 17018862 . S2CID 10475263 . Ono A, Kono K, Ikebe D, Muto A, Sun J, Kobayashi M, Ueda K, Melo JV, Igarashi K, Tashiro S (January 2007). "Nuclear positioning of the BACH2 gene in BCR-ABL positive leukemic cells". Genes, Chromosomes & Cancer . 46 (1): 67–74. doi :10.1002/gcc.20390 . PMID 17044046 . S2CID 13276741 . Ikeda T, Shibata J, Yoshimura K, Koito A, Matsushita S (March 2007). "Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapy" . The Journal of Infectious Diseases . 195 (5): 716–25. doi :10.1086/510915 PMID 17262715 . Hoshino H, Nishino TG, Tashiro S, Miyazaki M, Ohmiya Y, Igarashi K, Horinouchi S, Yoshida M (May 2007). "Co-repressor SMRT and class II histone deacetylases promote Bach2 nuclear retention and formation of nuclear foci that are responsible for local transcriptional repression". Journal of Biochemistry . 141 (5): 719–27. CiteSeerX 10.1.1.326.4123 doi :10.1093/jb/mvm073 . PMID 17383980 .
External links
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
