Applegate may refer to:

• Applegate, California, United States
• Applegate, Michigan, United States
• Applegate, Oregon, United States
• Applegate Peak in Oregon
• The Applegate River in Oregon
  • Applegate Lake, on the Applegate River
  • Applegate Valley, along the Applegate River
  • Applegate Valley AVA, an American Viticultural Area
• Applegate Trail, a pioneer trail through the Oregon Territory
• Applegate language, a language in the Athabaskan group
• Applegate tribe, a Native American people

• Applegate (surname)

• All pages with titles beginning with Applegate
• All pages with titles containing Applegate
• Apple (disambiguation)
• Gate (disambiguation)
• Mr. Applegate (disambiguation)