Andrew Hamilton may refer to:

• Andrew Hamilton (footballer, born 1873) (1873–1929), Scottish footballer
• Andrew Hamilton (footballer, born 1882) (1882–1915), Scottish footballer
• Andrew Hamilton (New Jersey governor) (died 1703), colonial governor of New Jersey
• Andrew Hamilton (lawyer) (1676–1741), attorney for John Peter Zenger in libel case, and Pennsylvania Attorney General
• Andrew Jackson Hamilton (1815–1875), US congressman and provisional governor of Texas
• Andrew H. Hamilton (1834–1895), US congressman
• Andrew D. Hamilton (born 1952), British chemist, President of New York University, and former Vice-Chancellor of the University of Oxford
• Andrew Hamilton (rugby league) (born 1971), Australian rugby league player
• Andrew Hamilton (canoeist), British canoeist
• Andrew Hamilton (priest) (died 1754), Anglican priest in Ireland
• Andrew Hamilton, Lord Redhouse (c.1565–1634), Scottish landowner and Senator of the College of Justice.

Andy Hamilton may refer to:

• Andy Hamilton (born 1954), British entertainer
• Andy Hamilton (jazz saxophonist) (1918–2012), Jamaican-born British jazz saxophonist
• Andy Hamilton (American football) (born 1950), American football player
• Andy Hamilton (pop saxophonist) (born 1953), British pop saxophonist
• Andy Hamilton (darts player) (born 1967), British darts player
• Andy Hamilton (author) (born 1974), British author