Alfonso Rodriguez may refer to:

• Alphonsus Rodriguez (1532–1617), Jesuit brother, Roman Catholic Saint
• Alfonso Rodríguez Olmedo (1598–1628), Spanish Jesuit priest and martyr
• Alonso Rodriguez (1538–1616), author of The Practice of Christian and Religious Perfection
• Alfonso Rodriguez Jr. (born 1953), American sentenced to death penalty for murder
• Alfonso Rodríguez (director) (born 1957), Dominican actor, writer and director
• Alfonso Rodríguez (gymnast) (born 1965), Spanish Olympic gymnast
• Alfonso Rodríguez (Captain), 17th-century Spanish mariner and merchant
• Alfonso Rodríguez (sport shooter) (born 1929), Colombian sport shooter
• Alfonso Rodríguez (weightlifter) (born 1948), Puerto Rican Olympic weightlifter
• Alfonso Rodríguez Salas (1939–1994), Spanish footballer
• Alfonso Rodríguez (athlete), Mexican athlete in 1977 Central American and Caribbean Championships in Athletics