AAAS may refer to:

• American Academy of Arts and Sciences ("AAAS" or "AAA&S"), a learned society and center for policy research; the publisher of the journal Dædalus
• American Association for the Advancement of Science, an organization that supports scientific collaboration, education, and outreach; the publisher of the journal Science
• Association for Asian American Studies, an organization that promotes teaching and research in Asian American studies
• Associate of the American Antiquarian Society
• AAAS (gene), a human gene responsible for triple-A syndrome (achalasia, adrenocortical insufficiency, alacrimia)