Singles
2022 Monterrey Challenger
Final
Champion	Fernando Verdasco
Runner-up	Prajnesh Gunneswaran
Score	4–6, 6–3, 7–6(7–3)
Events
Singles Doubles
← 2020 · Monterrey Challenger · 2023 →

Adrian Mannarino was the defending champion^[1] but chose not to defend his title.

Fernando Verdasco won the title after defeating Prajnesh Gunneswaran 4–6, 6–3, 7–6^(7–3) in the final.

	Semifinals							Final
	1	Fernando Verdasco	4	6	6
		Christian Harrison	6	4	2
								1	Fernando Verdasco	4	6	77
								7	Prajnesh Gunneswaran	6	3	63
	7	Prajnesh Gunneswaran	67	77	6
	PR	Go Soeda	79	64	4

	First round							Second round							Quarterfinals							Semifinals
	1	F Verdasco	6	6
	PR	Z Li	4	2				1	F Verdasco	6	6
	Q	A Kovacevic	6	6				Q	A Kovacevic	4	2
	Q	N Nakagawa	2	2											1	F Verdasco	6	6
	Q	W Blumberg	6	3	0											M Mmoh	3	2
		R Hijikata	2	6	6				R Hijikata	77	1	4
		M Mmoh	6	6					M Mmoh	65	6	6
	6	M Janvier	4	4																		1	F Verdasco	4	6	6
	4	C-M Stebe	2	2																			C Harrison	6	4	2
		B Tomic	6	6					B Tomic	2	5
	Q	S Shimabukuro	3	5					C Harrison	6	7
		C Harrison	6	7												C Harrison	6	6
		K Uchida	3	3											8	G Blancaneaux	4	2
		T Robredo	6	6					T Robredo	3	1
	WC	A Hernández	2	6	4			8	G Blancaneaux	6	6
	8	G Blancaneaux	6	2	6

	First round							Second round							Quarterfinals							Semifinals
	7	P Gunneswaran	6	6
	WC	R Harrison	3	4				7	P Gunneswaran	77	6
		A Rybakov	7	6					A Rybakov	61	1
	PR	R Statham	5	3											7	P Gunneswaran	1	7	6
	Q	E Zhu	6	6											3	J Jung	6	5	4
	WC	Milledge Cossu	1	2				Q	E Zhu	2	5
	Q	S Kirchheimer	4	1				3	J Jung	6	7
	3	J Jung	6	6																		7	P Gunneswaran	67	77	6
	5	JP Ficovich	6	7																		PR	G Soeda	79	64	4
		P Krstin	2	5				5	JP Ficovich	6	2	2
		V Durasovic	2	77	3			PR	G Soeda	2	6	6
	PR	G Soeda	6	60	6										PR	G Soeda	4	77	6
	PR	U Blanch	6	4	6										PR	U Blanch	6	65	4
		J Lenz	3	6	2			PR	U Blanch	77	6
		T-l Wu	4	3				2	J Clarke	64	2
	2	J Clarke	6	6

• Main draw
• Qualifying draw