The 2021 Mr. Olympia contest was a weekend-long IFBB Pro League professional bodybuilding competition that was held on October 8–9, 2021, in The Orange County Convention Center in Orlando, Florida. Mamdouh Elssbiay won the years' edition of Mr. Olympia.

The Orange County Convention Center in Orlando, Florida, was the host building for the crowning of multiple world champions in bodybuilding and fitness. Because of the challenges of the pandemic, the organizers served the 2021 Olympia as a celebration of overcoming numerous forms of adversity to reach the pinnacle in fitness. As in previous years, the show was streamed live to a global audience.^[1]

Place[2]	Prize	Name	Country	Judging	Finals	Total
1	$400,000	Mamdouh Elssbiay		7	5	12
2	$150,000	Brandon Curry		8	11	19
3	$100,000	Hadi Choopan		15	14	29
4	$40,000	Hunter Labrada		20	20	40
5	$35,000	Nick Walker		24	25	49
6		William Bonac		30	30	60
7		Iain Valliere		35	35	70
8		Justin Rodriguez		40	42	82
9		Akim Williams		49	48	97
10		Mohamed Shaaban		53	47	100
11		Roelly Winklaar		51	55	106
12		James Hollingshead		60	65	125
13		Hassan Mostafa		65	62	127
14		Patrick Moore		70	68	138
15		Regan Grimes		75	75	150
16		Andrea Presti		80	80	160

1. Chris Bumstead $50,000
2. Terrence Ruffin $15,000
3. Breon Ansley $10,000
4. Urs Kalecinski $5,000
5. Ramon Rocha Querioz N/A ^[3]

1. Brandon Hendrickson $50,000
2. Erin Banks $15,000
3. Diogo Montenegro $10,000
4. Kyron Holden N/A
5. Raymont Edmonds N/A ^[4]