The 2015–16 UEFA Women's Champions League knockout phase began on 7 October 2015 and concluded on 26 May 2016 with the final at Mapei Stadium – Città del Tricolore in Reggio Emilia, Italy, which decided the champions of the 2015–16 UEFA Women's Champions League. A total of 32 teams competed in the knockout phase.^[1]

Times from 25 October 2015 up to 26 March 2016 (round of 16 and quarter-finals first legs) were CET (UTC+1), all other times were CEST (UTC+2).

The schedule of the competition was as follows (all draws were held at the UEFA headquarters in Nyon, Switzerland).^[2]

Round	Draw	First leg	Second leg
Round of 32	20 August 2015, 13:30	7–8 October 2015	14–15 October 2015
Round of 16	19 October 2015, 13:30	11–12 November 2015	18–19 November 2015
Quarter-finals	27 November 2015, 13:30	23–24 March 2016	30–31 March 2016
Semi-finals		23–24 April 2016	30 April – 1 May 2016
Final		26 May 2016 at Mapei Stadium – Città del Tricolore, Reggio Emilia

The knockout phase involved 32 teams: 24 teams which qualified directly, and the eight group winners from the qualifying round.^[1]

Each tie in the knockout phase, apart from the final, was played over two legs, with each team playing one leg at home. The team that scored more goals on aggregate over the two legs advanced to the next round. If the aggregate score was level, the away goals rule was applied, i.e. the team that scored more goals away from home over the two legs advanced. If away goals were also equal, then 30 minutes of extra time was played. The away goals rule was again applied after extra time, i.e. if there were goals scored during extra time and the aggregate score was still level, the visiting team advanced by virtue of more away goals scored. If no goals were scored during extra time, the tie was decided by penalty shoot-out. In the final, which was played as a single match, if scores were level at the end of normal time, extra time was played, followed by penalty shoot-out if scores remained tied.

The mechanism of the draws for each round was as follows:

• In the draw for the round of 32, the sixteen teams with the highest UEFA coefficients were seeded (with the title holders being the automatic top seed), and the other sixteen teams were unseeded. The seeded teams were drawn against the unseeded teams, with the seeded teams hosting the second leg. Teams from the same association could not be drawn against each other.
• In the draw for the round of 16, the eight teams with the highest UEFA coefficients were seeded (with the title holders being the automatic top seed should they qualify), and the other eight teams were unseeded. The seeded teams were drawn against the unseeded teams, with the seeded teams hosting the second leg. Teams from the same association could not be drawn against each other.
• In the draws for the quarter-finals onwards, there were no seedings, and teams from the same association could be drawn against each other.

Below are the 32 teams which participated in the knockout phase (with their 2015 UEFA club coefficients, which took into account their performance in European competitions from 2010–11 to 2014–15 plus 33% of their association coefficient from the same time span).^[3][4]

Bye to round of 32 Team Coeff Frankfurt (Title holders) 72.680 Lyon 115.080 Wolfsburg 97.680 Rosengård 69.295 Paris Saint-Germain 59.080 Brøndby 52.870 Fortuna Hjørring 50.870 Glasgow City 38.570 Zvezda Perm 37.520 Barcelona 36.530 Zürich 32.910 Bayern Munich 31.680 Zorky Krasnogorsk 29.520 Liverpool 24.140 AGSM Verona 20.550 KIF Örebro 20.295 Standard Liège 19.610 Chelsea 19.140 St. Pölten-Spratzern 14.725 Brescia 14.550 Slavia Praha 13.560 Atlético Madrid 13.530 BIIK Kazygurt 12.940 Lillestrøm SK 12.075

Advanced from qualifying round Group Winners Coeff 1 FC Minsk 5.130 2 PAOK 12.965 3 Stjarnan 12.610 4 Twente 14.610 5 Olimpia Cluj 17.620 6 Spartak Subotica 15.620 7 Medyk Konin 11.105 8 PK-35 Vantaa 13.290

	Round of 32						Round of 16						Quarter-finals						Semi-finals						Final
	Chelsea	1	3	4
	Glasgow City	0	0	0
							Chelsea	1	0	1
							Wolfsburg	2	2	4
	Spartak Subotica	0	0	0
	Wolfsburg	0	4	4
													Wolfsburg	3	3	6
													Brescia	0	0	0
	Brescia	1	1	2
	Liverpool	0	0	0
							Brescia	1	1	2
							Fortuna Hjørring	0	1	1
	FC Minsk	0	0	0
	Fortuna Hjørring	2	4	6
																			Wolfsburg	4	0	4
																			Frankfurt	0	1	1
	Lillestrøm SK	1	1	2
	Zürich	0	1	1
							Lillestrøm SK	0	2	2
							Frankfurt (p)	2	0	2
	Standard Liège	0	0	0
	Frankfurt	2	6	8
													Frankfurt (p)	1	0	1
													Rosengård	0	1	1
	AGSM Verona	5	2	7
	St. Pölten-Spratzern	4	2	6
							AGSM Verona	1	1	2
							Rosengård	3	5	8
	PK-35 Vantaa	0	0	0
	Rosengård	2	7	9
																									Wolfsburg			1
																									Lyon (p)			1
	Atlético Madrid	0	3	3
	Zorky Krasnogorsk	2	0	2
							Atlético Madrid	1	0	1
							Lyon	3	6	9
	Medyk Konin	0	0	0
	Lyon	6	3	9
													Lyon	9	0	9
													Slavia Praha	1	0	1
	Slavia Praha	4	0	4
	Brøndby	1	1	2
							Slavia Praha	2	0	2
							Zvezda Perm	1	0	1
	Zvezda Perm	3	3	6
	Stjarnan	1	1	2
																			Lyon	7	1	8
																			Paris Saint-Germain	0	0	0
	Bayern Munich	1	2	3
	Twente (a)	1	2	3
							Twente	0	0	0
							Barcelona	1	1	2
	BIIK Kazygurt	1	1	2
	Barcelona	1	4	5
													Barcelona	0	0	0
													Paris Saint-Germain	0	1	1
	PAOK	0	0	0
	KIF Örebro	3	5	8
							KIF Örebro	1	0	1
							Paris Saint-Germain (a)	1	0	1
	Olimpia Cluj	0	0	0
	Paris Saint-Germain	6	9	15

The draw for the round of 32 was held on 20 August 2015.^[5][6]

Seeded	Unseeded
Frankfurt Lyon Wolfsburg Rosengård Paris Saint-Germain Brøndby Fortuna Hjørring Glasgow City Zvezda Perm Barcelona Zürich Bayern Munich Zorky Krasnogorsk Liverpool AGSM Verona KIF Örebro	Standard Liège Chelsea Olimpia Cluj[†] Spartak Subotica[†] St. Pölten-Spratzern Twente[†] Brescia Slavia Praha Atlético Madrid PK-35 Vantaa[†] PAOK[†] BIIK Kazygurt Stjarnan[†] Lillestrøm SK Medyk Konin[†] FC Minsk[†]

Notes

The first legs were played on 7 and 8 October, and the second legs were played on 14 and 15 October 2015.

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
BIIK Kazygurt	2–5	Barcelona	1–1	1–4
Medyk Konin	0–9	Lyon	0–6	0–3
Olimpia Cluj	0–15	Paris Saint-Germain	0–6	0–9
Slavia Praha	4–2	Brøndby	4–1	0–1
Standard Liège	0–8	Frankfurt	0–2	0–6
PAOK	0–8	KIF Örebro	0–3	0–5
Twente	3–3 (a)	Bayern Munich	1–1	2–2
Atlético Madrid	3–2	Zorky Krasnogorsk	0–2	3–0
St. Pölten-Spratzern	6–7	AGSM Verona	4–5	2–2
Stjarnan	2–6	Zvezda Perm	1–3	1–3
Lillestrøm SK	2–1	Zürich	1–0	1–1 (a.e.t.)
Chelsea	4–0	Glasgow City	1–0	3–0
PK-35 Vantaa	0–9	Rosengård	0–2	0–7
FC Minsk	0–6	Fortuna Hjørring	0–2	0–4
Spartak Subotica	0–4	Wolfsburg	0–0	0–4
Brescia	2–0	Liverpool	1–0	1–0

Barcelona won 5–2 on aggregate.

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Lyon won 9–0 on aggregate.

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Paris Saint-Germain won 15–0 on aggregate.

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Slavia Praha won 4–2 on aggregate.

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Frankfurt won 8–0 on aggregate.

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KIF Örebro won 8–0 on aggregate.

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3–3 on aggregate. Twente won on away goals.

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Atlético Madrid won 3–2 on aggregate.

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AGSM Verona won 7–6 on aggregate.

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Zvezda Perm won 6–2 on aggregate.

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Lillestrøm SK won 2–1 on aggregate.

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Chelsea won 4–0 on aggregate.

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Rosengård SK won 9–0 on aggregate.

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Fortuna Hjørring won 6–0 on aggregate.

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Wolfsburg won 4–0 on aggregate.

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Brescia won 2–0 on aggregate.

The draw for the round of 16 was held on 19 October 2015.^[7][8][9]

Seeded	Unseeded
Frankfurt Lyon Wolfsburg Rosengård Paris Saint-Germain Fortuna Hjørring Zvezda Perm Barcelona	AGSM Verona KIF Örebro Chelsea Twente Brescia Slavia Praha Atlético Madrid Lillestrøm SK

The first legs were played on 11 and 12 November, and the second legs were played on 18 and 19 November 2015.

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
Twente	0–2	Barcelona	0–1	0–1
Brescia	2–1	Fortuna Hjørring	1–0	1–1
Atlético Madrid	1–9	Lyon	1–3	0–6
Slavia Praha	2–1	Zvezda Perm	2–1	0–0
Chelsea	1–4	Wolfsburg	1–2	0–2
KIF Örebro	1–1 (a)	Paris Saint-Germain	1–1	0–0
AGSM Verona	2–8	Rosengård	1–3	1–5
Lillestrøm SK	2–2 (4–5 p)	Frankfurt	0–2	2–0 (a.e.t.)

Barcelona won 2–0 on aggregate.

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Brescia won 2–1 on aggregate.

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Lyon won 9–1 on aggregate.

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Slavia Praha won 2–1 on aggregate.

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Wolfsburg won 4–1 on aggregate.

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1–1 on aggregate. Paris Saint-Germain won on away goals.

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Rosengård won 8–2 on aggregate.

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2–2 on aggregate. Frankfurt won 5–4 on penalties.

The draws for the quarter-finals and semi-finals were held on 27 November 2015.^[10][11] The first legs were played on 23 March, and the second legs were played on 30 March 2016.

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
Wolfsburg	6–0	Brescia	3–0	3–0
Rosengård	1–1 (4–5 p)	Frankfurt	0–1	1–0 (a.e.t.)
Lyon	9–1	Slavia Praha	9–1	0–0
Barcelona	0–1	Paris Saint-Germain	0–0	0–1

Wolfsburg won 6–0 on aggregate.

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1–1 on aggregate. Frankfurt won 5–4 on penalties.

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Lyon won 9–1 on aggregate.

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Paris Saint-Germain won 1–0 on aggregate.

The first legs were played on 24 April, and the second legs were played on 1 and 2 May 2016.

Team 1	Agg.Tooltip Aggregate score	Team 2	1st leg	2nd leg
Lyon	8–0	Paris Saint-Germain	7–0	1–0
Wolfsburg	4–1	Frankfurt	4–0	0–1

Lyon won 8–0 on aggregate.

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Wolfsburg won 4–1 on aggregate.

The final was played on 26 May 2016 at the Mapei Stadium – Città del Tricolore in Reggio Emilia, Italy.

• 2015–16 UEFA Women's Champions League