2011 Eastern Illinois Panthers football
Conference	Ohio Valley Conference
Record	2–9 (1–7 OVC)
Head coach	Bob Spoo (24th season)
Offensive coordinator	Roy Wittke (17th season)
Defensive coordinator	Roc Bellantoni (10th season)
Home stadium	O'Brien Field
Seasons ← 2010 2012 →

The 2011 Eastern Illinois Panthers football team represented Eastern Illinois University as a member of the Ohio Valley Conference (OVC) during the 2011 NCAA Division I FCS football season. Led by Bob Spoo in his 24th and final year as head coach, the Panthers compiled an overall record of 2–9 with a mark of 1–7 in conference play, placing last out of nine teams in the OVC. Eastern Illinois played home games at O'Brien Field in Charleston, Illinois.

Date	Time	Opponent	Site	TV	Result	Attendance
September 1	6:30 pm	Illinois State*	O'Brien Field Charleston, IL (rivalry)	CSN Chicago	W 33–26	9,111
September 10	2:30 pm	at Northwestern*	Ryan Field Evanston, IL	BTN	L 21–42	28,042
September 17	6:30 pm	Tennessee Tech	O'Brien Field Charleston, IL		L 20–31	6,157
September 24	6:00 pm	at No. 16 Jacksonville State	JSU Stadium Jacksonville, AL		L 21–28	14,813
October 1	6:00 pm	at Southeast Missouri State	Houck Stadium Cape Girardeau, MO		L 30–37	7,757
October 8	1:30 pm	Eastern Kentucky	O'Brien Field Charleston, IL	WEIU	L 16–48	9,063
October 15	3:00 pm	at Murray State	Roy Stewart Stadium Murray, KY		L 27–36	7,857
October 22	1:30 pm	UT Martin	O'Brien Field Charleston, IL	WEIU	L 23–24	6,832
October 29	4:00 pm	at Austin Peay	Governors Stadium Clarksville, TN		W 19–10	5,273
November 5	1:30 pm	Tennessee State	O'Brien Field Charleston, IL	WEIU	L 17–18	6,774
November 12	2:00 pm	at Southern Illinois*	Saluki Stadium Carbondale, IL		L 28–45	7,447
*Non-conference game Homecoming Rankings from The Sports Network Poll released prior to the game All times are in Central time