The 2005-06 edition of Copa del Rey de Balonmano was disputed in Almería-Vera, Andalusia. The tournament was played by the 8 first of the Liga ASOBAL when reach the half of the league.

10 May 2006:

• BM Valladolid 36-32 Caja España Ademar León:
• BM Granollers 25-27 FC Barcelona Handbol:

11 May 2006:

• Portland San Antonio 32-35 BM Ciudad Real:
• Keymare Almería 31-34 CAI BM Aragón:

13 May 2006:

• BM Ciudad Real 35-32 CAI BM Aragón:
• BM Valladolid 31-29 FC Barcelona Handbol:

14 May 2006:

• BM Valladolid 35-30 BM Ciudad Real

• Liga ASOBAL
• Handball in Spain