The 1921–22 season of the Romanian Football Championship was the tenth edition of the top-level football league of Romania and it also marked the inception of Romania's first official national football championship, which featured teams from across the entire territory of Greater Romania. Chinezul Timișoara became champions for the first time in their history.

The competition was structured in two phases: an initial regional phase, with its own tournament, followed by a knockout stage featuring the regional champions to determine the national champion. The inaugural championship involved 7 regional champions, representing Arad, Bucharest, Timișoara, Brașov and Sibiu (with separate competitions in the fall, but with the consolidation of the best teams into a new championship in the spring), Cluj (including Târgu Mureș), Oradea (Oradea Mare, as it was called at the time, including Satu Mare, Carei, and Salonta) and Cernăuți. While regional matches were played in a home-and-away format, the final tournament matches were held as knockout games on the home ground of one of the competing teams.

Tricolor Buc.

Chinezul

AMEFA

Stăruința Oradea

Victoria Cluj

SG Sibiu

Polonia Cernăuți

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Location of regional champions in Greater Romania

¹ The team from Sibiu failed to appear, so by administrative decision they forfeited the game.

² The team from Arad received a bye from the quarterfinals.

23 July 1922

18:00

Polonia Cernăuți	0–1	Tricolor București
		Fianu 55'

Boisko Polskie, Cernăuți

Referee: Lajos Nagy (Cluj)

27 August 1922

Victoria Cluj	2–2	Stăruința Oradea
Barabás II 16' 56'		Ströck II 32' Bartha 66'

Orășenesc, Cluj

Referee: Steinhübel Zoltán (Arad)

7 September 1922

Victoria Cluj	2–0	Stăruința Oradea
Barta 20' (pen.) Cipcigan 80'

Orășenesc, Cluj

Referee: Steinhübel Zoltán (Arad)

³ The team from Bucharest failed to appear, so by administrative decision they forfeited the game.

10 September 1922

Chinezul Timișoara	2–1	AMEF Arad
Frech II 44' Steiner 78'		Csapó 73'

Banatul, Timișoara

Referee: Kovács (Timișoara)