Willie Murphy may refer to:

• Willie Murphy (Cork hurler) (1915–1977), Irish hurler for Ballincollig and Cork, 1939–1949
• Willie Murphy (Kilkenny hurler) (fl. 1960s/1970s), Irish hurler for Rower-Inistioge and Kilkenny
• Willie Murphy (Wexford hurler) (born 1944), Irish hurler for Faythe Harriers and Wexford, 1965–1979
• Willie Murphy (baseball) (1864–?), baseball player
• Willie Murphy (musician) (1943–2019), American musician
• Willy Murphy (1937–1976), American underground cartoonist

• William Murphy (disambiguation)