William Rhodes may refer to:

• William Rhodes (cricketer, born 1883) (1883–1941), British cricketer
• William Rhodes (cricketer, born 1936) (1936–2005), British cricketer
• William Rhodes (footballer), soccer player
• Billy Rhodes (Welsh rugby league), Welsh rugby league footballer who played in the 1920s for Wales, Pontypridd, and Warrington
• Billy Rhodes (English rugby league), English rugby league footballer who played in the 1910s and 1920s, and coached in the 1920s through to the 1950s
• Trevor Rhodes (footballer, born 1909) (William Trevor Rhodes, 1909–1993), English footballer
• William Rhodes (American football) (1869–1914), American football player and coach
• Will Rhodes (born 1995), English cricketer

• William Barnard Rhodes (1807–1878), New Zealand businessman and politician (known as Barnard Rhodes)
• William C. Rhodes (New York politician), New York newspaper editor and politician
• William C. Rhodes (businessman), American businessman, CEO of AutoZone
• William R. Rhodes (born 1935), American businessman with Citigroup and Citibank
• William Rhodes (Canadian politician) (1821–1892), politician in Quebec, Canada

• William Barnes Rhodes (1772–1826), English dramatist
• William Henry Rhodes (1822–1876), American writer, used the pseudonym "Caxton"
• William Rhodes (sculptor), American sculptor
• William Luther Rhodes (1918–1986), associate justice of the South Carolina Supreme Court
• William A. Rhodes (1916-2007), inventor and astronomer of Phoenix, Arizona