William Frankland may refer to:

• William Frankland (died 1640), of Thirkleby, MP for Thirsk during the reign of Charles I
• Sir William Frankland, 1st Baronet (c. 1640–1697), of Thirkleby, English politician, MP for Thirsk
• William Frankland (died 1714), FRS, son of Sir Thomas Frankland, 2nd Baronet
• William Frankland (1720–1805), East India Company merchant and MP for Thirsk
• William Frankland (1761–1816), English politician and Lord Commissioner of the Admiralty
• William Howard Frankland (1901–1980), American businessman
• William Frankland (allergist) (1912–2020), British allergist and immunologist