A vaccine is a biological preparation that provides immunity to an infectious disease.

Vaccine or The Vaccine(s) may also refer to:

• Vaccine (journal), a medical journal
• Vaccine: The Controversial Story of Medicine's Greatest Lifesaver, a 2007 book by Arthur Allen
• Vaccine (instrument), a Haitian musical instrument
• Vaccine (musician), Christine Clements, American dubstep record producer
• "Vaccine" (song), by NoCap
• "Vaccine", a song by Logic from Bobby Tarantino III
• "Vaccine", a song by Mew from No More Stories..., 2009
• "Vaccine", a song by Migos from Culture III
• "The Vaccine" (The Outer Limits), a television episode
• The Vaccines, an English rock band
• COVID-19 vaccine, colloquially referred to as "The Vaccine"

• Vaccination, the process of administering a vaccine
• Vaccine hesitancy, a reluctance or refusal to be vaccinated or to have one's children vaccinated
• Vaxine, a video game