U.S. Highway 49W
Route information
Maintained by MDOT
Length	89.3 mi[1] (143.7 km) (81.894 mi according to state mileage)
Existed	1932–present
Major junctions
South end	US 49 / US 49E in Yazoo City
Major intersections	MS 3 in Yazoo City MS 149 in Silver City MS 7 / MS 12 in Belzoni US 82 in Indianola MS 8 in Ruleville MS 32 in Parchman
North end	US 49 / US 49E / MS 3 in Tutwiler
Location
Country	United States
State	Mississippi
Counties	Yazoo, Humphreys, Sunflower, Coahoma, Tallahatchie
Highway system
United States Numbered Highway System List Special Divided Mississippi State Highway System Interstate US State
← US 49E → MS 50

U.S. Route 49W (US 49W) is an 89.3-mile-long (143.7 km) U.S. Highway in the Delta region of Mississippi, passing through Yazoo, Humphreys, Sunflower, and Tallahatchie counties.

US 49W begins just north of downtown Yazoo City at an interchange between US 49 and US 49E. It heads northwest to have an interchange with and become concurrent with MS 3 before leaving Yazoo City and crossing over the Yazoo River. The highway then crosses into Humphreys County just southwest of Carter.

US 49W/MS 3 now cross over the Will M. Whittington Auxiliary Channel and Lake Atchaflya before passing through Silver City and having an intersection with MS 149. The highway continues north, paralleling the Yazoo River, to pass through Belzoni, where it bypasses downtown along its west side and has a short concurrency with MS 12 and an intersection with MS 7. US 49W/MS 3 continue northwest to pass through Isola, where it has an intersection with unsigned MS 806 (Belzoni Street) and crosses over Lake Dawson, before entering Sunflower County.

The highway passes through Caile and Inverness, where it intersects another section of MS 149, before MS 3 splits off towards Moorhead near Baird. US 49W crosses over the Sunflower River to enter Indianola. It bypasses downtown along its east side, passing through neighborhoods to have an intersection with US 82. The highway then narrows to two-lanes to leave Indianola and cross the Sunflower River for a second time. Prior to this point, the entire route of US 49W is a four-lane highway. US 49W passes through Sunflower, where it intersects unsigned MS 810 and rejoins MS 3, before passing through Dwyer and Blaine. US 49W/MS 3 passes through Doddsville, where it has a short concurrency with MS 442 and intersects unsigned MS 832, and Cottondale before passing through Ruleville, where it has an intersection with unsigned MS 812 and MS 8. The highway passes through Drew, where it intersects unsigned MS 820, before passing by the Mississippi State Penitentiary, where it has an intersection with MS 32. US 49W/MS 3 passes through Rome before cutting a corner of Coahoma County. Soon after, the route reaches Tallahatchie County.

The highway passes northeast through rural areas for several miles before entering Tutwiler and coming to an end at a Y-Intersection between US 49 and US 49E, with MS 3 continuing north along US 49.^[2]

U.S. Route 49W didn't come about until 1932, when the US 49 split was made. The southern section of this route was designated for 4-laning under the 1987 Highway Program, and was also marked as NHS.

The highway previously traveled straight through downtown Yazoo City along what is now MS 149/MS 16 (Broadway Street). No trucks were allowed along this portion of the highway, with trucks forced to detour via routes on the edge of the city. In 2004, a completely new four-lane alignment between Yazoo City and Silver City opened. This had the effect of lengthening US 49, shortening US 49W, and allowing trucks to follow US 49W without detouring around the middle of Yazoo City. The former two-lane alignment of US 49W between Yazoo City and Silver City became part of MS 149 in 2006.^[3]

It is notable that for several years during the 1930s, a second split route existed on US 49 in South Mississippi, similar to but shorter than the split that still exists in the Delta region.^[4] Between Brooklyn and Hattiesburg, travelers had the option of a 24-mile-long (39 km) direct route via US 49W, or a somewhat shorter but broken route on US 49E, serving the Forrest County Agricultural High School and the small community of McLaurin, Mississippi.

County	Location	mi	km	Destinations	Notes
Yazoo	Yazoo City	0.0	0.0	US 49 south / US 49E north – Jackson, Greenwood	Interchange; US 49 splits into US 49W and US 49E
		0.97– 1.6	1.56– 2.6	MS 3 south – Yazoo City, Vicksburg	Interchange; south end of MS 3 overlap
Humphreys	Silver City	17.3	27.8	MS 149 south to MS 14 / MS 16 – Midnight, Louise	Northern terminus of Yazoo City-Silver City section of MS 149
	Belzoni	23.1	37.2	MS 12 east	South end of MS 12 overlap
		23.8	38.3	MS 7 north / MS 12 west (1st Street) – Indianola, Hollandale	North end of MS 12 overlap; southern terminus of MS 7
	Isola	31.1	50.1	S Belzoni Street (MS 806 north) – Downtown	Southern terminus of unsigned MS 806
		32.0	51.5	N Belzoni Street (MS 806 south) – Downtown	Northern terminus of unsigned MS 806
Sunflower	Inverness	37.5	60.4	MS 149 north (Old Highway 49W) – Downtown	Southern terminus of Inverness section of MS 149
		38.9	62.6	MS 149 south (Old Highway 49W) – Downtown	Northern terminus of Inverness section of MS 149
	​	40.0	64.4	MS 3 north – Moorhead, Mississippi Delta Community College	North end of MS 3 overlap
	Indianola	46.5	74.8	US 82 – Greenville, Greenwood
	Sunflower	54.6	87.9	MS 3 south – Moorhead, Mississippi Delta Community College	South end of MS 3 overlap
		55.1	88.7	Quiver Street (MS 810 west) – Downtown	Eastern terminus of unsigned MS 810
	Doddsville	62.9	101.2	MS 442 west – Shaw	South end of MS 442 overlap
		63.1	101.5	MS 442 east – Schlater 5th Avenue (MS 832 west) – Downtown	North end of MS 442 overlap; eastern terminus of unsigned MS 832
	Ruleville	67.5	108.6	Sunflower Street (MS 812 north) – Downtown	Southern terminus of unsigned MS 812
		68.6	110.4	MS 8 (Quiver Street) – Cleveland, Minter City
	Drew	74.3	119.6	Park Avenue (MS 820 west) – Downtown	Eastern terminus of unsigned MS 820
	Parchman	81.8	131.6	MS 32 east – Webb	Western terminus of eastern segment MS 32
Coahoma	No major junctions
Tallahatchie	Tutwiler	89.3	143.7	US 49 north (MS 3 north) / US 49E south – Clarksdale, Greenwood	North end of MS 3 overlap; US 49W and US 49E merge to form US 49
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

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