Departing from New London, Connecticut, on 31 May 1921, S-17 sailed via the Panama Canal, California, Hawaii, and Guam to the Philippines, arriving at Cavite, Luzon, on 1 December. In 1922, she sailed from Manila Bay on 11 October, visited Hong Kong from 14–28 October, and returned to Cavite on 1 November. Sailing from Manila on 15 May 1923, S-17 visited Shanghai, Yantai, and Qinhuangdao, before returning via Wusong and Amoy to Cavite on 11 September. In the summer of 1924, she visited Shanghai, Qingdao, Yantai, and Qinhuangdao, before returning via Yantai and Amoy to Olongapo, Luzon, on 23 September. Departing Cavite on 29 October, she arrived at Mare Island, California, on 31 December.
S-17 was recommissioned on 16 December 1940. After voyages to Bermuda, S-17 operated in the Panama Canal area from December 1941 to February 1942. On 28 February 1942, she was operating at periscope depth when a United States Marine Corps plane dropped a 100-pound (45.4 kg) bomb targeting her periscope.[1] Later in the day, the same or a different Marine Corps plane dropped a 100-pound (45.4 kg) bomb that landed within 50 yards (46 m) of her while she was on the surface. S-17 suffered no damage or casualties in either incident.[1]
S-17 operated from Saint Thomas in the United States Virgin Islands, in March 1942 and in the Panama Canal area again from April to August 1942. At 14:20 on 4 August 1942, a U.S. plane attacked her at 11°34′N078°36′W / 11.567°N 78.600°W / 11.567; -78.600 with four 500-pound (227 kg) depth charges while she was operating on the surface in the Caribbean Sea, inflicting damage that prevented her from diving. S-17′s crew identified the attacking aircraft as a U.S. Army Air Forces B-25 Mitchellbomber,[2] and one source describes it as a U.S. Navy PV-1 Venturapatrol bomber,[3][4] but an official report on the incident identifies the plane as a U.S. Army Air Forces B-18 Bolo bomber.[1]S-17 arrived at Coco Solo in the Panama Canal Zone on 8 August 1942 for repairs.[4]
S-17 operated from New London from September 1942 to July 1944. Her cruises from New London often included operations in Casco Bay, Maine.
Decommissioning and disposal
Decommissioned on 4 October 1944, S-17 was struck from the Naval Vessel Register on 13 November 1944. She was intentionally sunk on 5 April 1945.