USS Jackson may refer to:

• USS Jackson (LCS-6), an Independence-class littoral combat ship commissioned in 2015

• USRC Jackson, a revenue cutter in commission from 1832 to 1864
• USS Andrew Jackson, a ballistic missile submarine in commission from 1963 to 1989
• USS Fort Jackson, a steamer in commission from 1863 to 1865
• USS Henry M. Jackson, a ballistic missile submarine in commission since 1984
• USS John P. Jackson, a steamer in commission from 1862 to 1865
• USS Nellie Jackson, a patrol vessel in commission from 1917 to 1918
• USCGC Jackson, a sunken cutter which was in commission from 1927 to 1944
• USS President Jackson, an attack transport in commission from 1942 to 1955
• USS Stonewall Jackson, a ballistic missile submarine in commission from 1964 to 1995