Trujillo or Truxillo may refer to:

• Trujillo, Valle del Cauca, a municipality in the department of Valle del Cauca
• Trujillo Province (Gran Colombia), part of the historic republic from 1819 to 1831

• Ciudad Trujillo, the former name of the city of Santo Domingo

• Trujillo, Honduras, a municipality in the department of Colón

• Trujillo, Mexico, a city

• Trujillo, Peru, a city in the province of Trujillo
• Trujillo metropolitan area (Peru), a metropolitan area of Trujillo city
• Historic Centre of Trujillo
• Trujillo District, a district in the province of Trujillo
• Trujillo Province, Peru, a province in the region of La Libertad

• Trujillo Alto, Puerto Rico, a municipality
• Trujillo Alto barrio-pueblo, a downtown and municipality seat
• Trujillo Bajo, Carolina, Puerto Rico, a barrio

• Trujillo, Cáceres, a municipality in the autonomous community of Extremadura
• Robledillo de Trujillo

• Trujillo, Colorado, a place in Archuleta County, Colorado
• Trujillo, Texas, an unincorporated community in Oldham County, Texas
• Truxillo, Virginia, an unincorporated community in Amelia County, Virginia

• Trujillo (state), one of the 23 states which make up the country
• Trujillo, Trujillo, a municipality in the state of Trujillo
• Trujillo Province (Venezuela), in existence from 1831 to 1864
• Trujillo Canton, a canton in former Trujillo Province

• Trujillo (surname)
• Rafael Trujillo, dictator of the Dominican Republic from 1930 to 1961
• CF Trujillo, a Spanish football team based in Trujillo, Cáceres
• Sport Coopsol Trujillo, a football club based in the city of Trujillo, Peru
• Trujillo (beer), Peruvian brand
• Trujillo Airport (IATA: TJI), serving Trujillo, Colón, Honduras
• Trujillo International Airport, serving Trujillo, Peru
• Trujillo River, a river in Mexico
• SS Trujillo, the last lake tanker to operate in Lake Maracaibo, retired in 1954

• Diocese of Trujillo (disambiguation), multiple dioceses