Tooth is a surname. Notable people with this surname include:

• Arthur Tooth (1839–1931), Church of England priest
• Charles Tooth (1831–1894), Anglican clergyman
• Dick Tooth (1929–2020), Australian rugby union player
• Douglas Tooth (1904–1982), Australian politician
• Howard Henry Tooth (1856–1925), British neurologist
• John Tooth (1803–1857), Australian brewer, founder of Tooth and Co.
• Liane Tooth (born 1962), Australian field hockey player
• Mary Tooth (1778–1843) British Methodist preacher
• Nicholas Tooth (1844–1913), foundry owner and Queensland politician
• Robert Tooth (1821–1893), British-born member of Tooths' brewery family in Sydney
• William Tooth (1823–1876), English-born Australian politician and pastoralist
• Lucas-Tooth baronets
  • Archibald Lucas-Tooth (1884–1918), 2nd baronet, son of Robert
  • Hugh Lucas-Tooth (1903–1985), Scottish politician
  • Robert Lucas-Tooth (1844–1915), Australian politician

• Tooth & Co., Sydney brewing company founded by the Tooth family