The Great Circle may refer to:

• Indiana Jones and the Great Circle, a 2024 Action-adventure game by MachineGames
• The Great Circle, a 1997 novel by Peter Prince
• The Great Circle, the journal of the Australian Association for Maritime History
• The Great Circle Tour, a 2017 world tour by the band Midnight Oil
• Great Circle Earthworks, a section of the Newark Earthworks in Ohio, US
• The Great Circle, the book series of Andromeda (novel)

• Great circle, the intersection of a sphere and a plane that passes through the center point of the sphere
• Great Circle (novel), a 2021 novel by Maggie Shipstead
• Indiana Jones and the Great Circle, a video game in the Indiana Jones franchise