This article is rated C-class on Wikipedia's content assessment scale. It is of interest to the following WikiProjects:

Chemicals: Core Mid‑importance This article is within the scope of WikiProject Chemicals, a daughter project of WikiProject Chemistry, which aims to improve Wikipedia's coverage of chemicals. To participate, help improve this article or visit the project page for details on the project.ChemicalsWikipedia:WikiProject ChemicalsTemplate:WikiProject Chemicalschemicals Mid This article has been rated as Mid-importance on the project's importance scale. This is a core article in the WikiProject Chemicals worklist. Environment Mid‑importance This environment-related article is part of the WikiProject Environment to improve Wikipedia's coverage of the environment. The aim is to write neutral and well-referenced articles on environment-related topics, as well as to ensure that environment articles are properly categorized. Read Wikipedia:Contributing FAQ and leave any messages at the project talk page.EnvironmentWikipedia:WikiProject EnvironmentTemplate:WikiProject EnvironmentEnvironment Mid This article has been rated as Mid-importance on the project's importance scale. Occupational Safety and Health Low‑importance This article is within the scope of WikiProject Occupational Safety and Health, a collaborative effort to improve the coverage of articles related to occupational safety and health on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.Occupational Safety and HealthWikipedia:WikiProject Occupational Safety and HealthTemplate:WikiProject Occupational Safety and HealthOccupational Safety and Health Low This article has been rated as Low-importance on the project's importance scale.

Is kt/a = kilotons/annum (kilotons/year) ? Also, are those metric tons or 2000 lbs tons ?
H Padleckas 13:13, 20 July 2005 (UTC)[reply]

• Hi, Henri, of course kt/a are thousand tonnes per annum, a very common abbreviation for that part of the world that uses tonnes of 1000 kg. Metric! The UK is going to metric very slowly: when does the US catch up? By the way: Excellent picture.

Wim van Dorst 19:49, 20 July 2005 (UTC).[reply]

The text in the section "Medical effects" comes directly word-for-word from the page listed as the first external link [http://www.atsdr.cdc.gov/tfacts118.html]. This text should be rewritten in order that it might not be an exact copy. Using the information in that article is acceptable, but just copying it is not (see Wikipedia:Copyrights). I am not sure if somehow Wikipedia has permission to reproduce that page and if so, please reply here; otherwise, rewrite that section. If there is no response here and no change to the article after 1 week, I will delete that section. KHenriksson 07:00, 9 July 2006 (UTC)[reply]

EGMBE

Butyl Glycol is often know, in the oil industry at least as EGMBE. I'm not very familiar with making edits in Wikipedia, but would someone be able to link EGMBE to this. Regards.

This is done. Redirect from EGMBE to this article. Brady8 22:07, 20 June 2007 (UTC)[reply]

Just a note to all that copying text directly from http://www.atsdr.cdc.gov/tfacts118.html or any other external website without permission constitutes copyright violation. I will continue to delete any copyrighted information unless it is rewritten and cited.VandalCruncher (talk) 15:26, 20 December 2007 (UTC)[reply]

I delinked the following link to ethylene glycol because I think it gives people the impression that this compound is identical to ethylene glycol:

OtherNames = butyl cellosolve<br />butyl glycol<br />[[Ethylene_glycol|ethylene glycol]] monobutyl ether

--Rifleman 82 (talk) 05:14, 31 December 2007 (UTC)[reply]

I just came across the name referring to both compounds on Google, I had a WFT moment. Ok, I'll run with this...hmm.. I had to call poison control cause a buddy did something stupid, they listed that compound with all the other ethylene. If I come across any ref that clarify the issue I'll make the changes and post the 411 here.Lyta79 (talk) 07:38, 31 December 2007 (UTC)[reply]

The reference was to California's Hazardous Substances List. EGBE is considered a hazardous substance. That is not the same as the California Toxic Air Contaminants List. Currently EGBE is not considered a toxic air contaminant by either California or the EPA. Sunraven 14:42, 08 December 2008

I don't know if it's necessary/warranted or not, but perhaps a list of products that contain this chemical? I was surprised to find that "LA's Totally Awesome" all purpose cleaner contains this chemical. I've used it a while now, and damn, the product does work good....I was kinda curious as to "what" or "how" the product works, since it says contains no acid, bleach, ammonia, etc....right on the bottle, well what's LEFT? lol. In fine print (it's bigger on their website though lol), it says Contains 2-Butoxy ethanol but doesn't give any cautionary information, why this is good/bad/etc....but yes, it's a good cleaner, and the dilution scale is quite high :) 20-1 (1 part LAs Totally Awesome) for some cleaning applications even... Not that it's a bad thing, I haven't experienced any of the side effects listed here, and like I said, I use it weekly, for my house cleaning tasks, it comes cheap, $1 at my local dollar store --72.188.76.225 (talk) 03:48, 10 May 2009 (UTC)[reply]

Charlie's Soap Laundry Pre-Spray may contain 2-Butoxyethanol acetate. Perhaps "LA's Totally Awesome" and Charlie's Soap Laundry Pre-Spray should redirect here.

It is in at least one non-hardening pipe joint compound, Mill-Rose Company's Blue Monster Compound with PTFE. John (talk) 09:07, 4 November 2012 (UTC)John[reply]

During several automated bot runs the following external link was found to be unavailable. Please check if the link is in fact down and fix or remove it in that case!

* http://ia331209.us.archive.org/0/items/AirFoamHdMaterialDataSafetySheetmsds/ ** In [[2-Butoxyethanol]] on 2011-05-25 06:55:18, Socket Error: 'getaddrinfo failed' ** In [[2-Butoxyethanol]] on 2011-06-10 04:43:16, Socket Error: 'getaddrinfo failed'

--JeffGBot (talk) 04:43, 10 June 2011 (UTC)[reply]

During several automated bot runs the following external link was found to be unavailable. Please check if the link is in fact down and fix or remove it in that case!

• http://www.eastman.com/Product_Information/ProductHome.asp?Product=71000130
  • In 2-Butoxyethanol on 2011-05-25 06:55:21, 404 NOT FOUND
  • In 2-Butoxyethanol on 2011-06-10 04:43:18, 404 NOT FOUND

--JeffGBot (talk) 04:43, 10 June 2011 (UTC)[reply]

"Butyl Cellosolve" is much better know and more searched than the chemical name. Findable.

"Butyl Celosolve" is a common misspelling, which should also redirect here.

•  Done. I have created redirects for those terms. -- Ed (Edgar181) 12:39, 26 June 2012 (UTC)[reply]

Butyl celosolve is not a common misspelling (only 38 hits on startpage, for instance) whereas butyl cellusolve (sic) yields 742.JThaden (talk) 09:04, 4 November 2012 (UTC)JThaden[reply]

Please refer to page 7 of this attachment of the congressional report on "CHEMICALS USED IN HYDRAULIC FRACTURING". http://democrats.energycommerce.house.gov/sites/default/files/documents/Hydraulic-Fracturing-Chemicals-2011-4-18.pdf — Preceding unsigned comment added by 24.187.208.114 (talk) 10:31, 25 September 2013 (UTC)[reply]

For the 2-butoxyethanol page, we would like to begin by expanding on production and uses. In particular, we would like to include more information on the involvement on 2-butoxyethanol in fracking. We would like to clarify the conflicting reports on the carcinogenic properties of 2-butoxyethanol, in addition to supplying more general health information. We would like to expand on the effects that it has on humans and other animals. The environment effects section is currently minimal, so we would like to expand on how it moves through the environment. In particular, its solubility in water, air, and soil and how that affects where it exists. Comparison of different measurements of 2-butoxyethanol in the environment will also be included. Our plan is to keep the general format and content of the article, and to simply expand upon relevant information. Blairwal (talk) 20:21, 17 February 2014 (UTC) Custodim (talk) 20:22, 17 February 2014 (UTC) Kglobalhealth (talk) 20:23, 17 February 2014 (UTC)[reply]

Intro:

• I don’t really get a sense of what the chemical does until the last sentence of the intro, so add that it’s a solvent in the first sentence. Maybe also mention some of the main things it’s used in, which would definitely generate interest for the rest of the article. I would also add something about it being a carcinogen
  

Production:

• change “the main routes” to something like “to yield/produce 2-butoxyethanol”…or maybe switch sentence to make butanol and ethylene oxide the subjects.
  

Uses:

• I like the background on glycol ethers. Is 2-buto in the E series or P series?
  
• It seems like the second paragraph that begins with “In 2006” would fit better under the production heading
  
• I’m unsure as to what an indirect food additive is…either wikilink or explain this
  
• “When liquid is pumped into the well, 2-Butoxyethanol is used to stabilize the fracturing fluids that are being pumped under extreme pressure by lowering the surface tension and to facilitate release of the oil by preventing congealing” this sentence is too long and complex, and needs verb agreement between “lowering” and “to facilitate”
  
• It might be useful to split this up into subheadings by industry
  

Safety:

• you should combine “environmental fate” with “disposal and degradation,” as they convey the same message
  
• I would put regulation after animal studies, because human exposure and animal studies are more logically linked
  

Intro:

• This paragraph seems contradictory in saying that it’s not a carcinogen in humans and is not reported as such, but should be handled with extreme caution
  
• Most of this info would fit better under animal studies. Perhaps the first paragraph should just convey that it is a possible carcinogen, and has been tested in rats and humans.
  

Human Exposure:

• the phrase “odor threshold” is confusing. Does this mean that if you can smell it, you are definitely above the threshold for exposure?
  

regulation in Canada:

• “these products are not required..” these doesn’t have an antecedent
  
• what point of dilution is needed to be legally unreported?
  
• “The safety of the products as normally used” – confusing. Does this mean these groups defend its use, and oppose the concerns of the CEPA?
  

Animal Studies:

• I don’t know what Fischer 344 rats are. Is this detail significant in the study?
  
• This is a really clear paragraph that flows well
  

Overall:

• make sure to use either 2-butoxyethanol or simply butoxyethanol the entire time, because the switching in the middle of the article gave me the impression you were talking about different molecules
  
• I am still left with some questions: what specific level are you using to designate high, moderate, and low levels? As a consumer using many of these products, is the level of exposure on a daily basis possibly damaging?
  
• consolidate your references by using < ref name= “author”/ > to eliminate redundancies
  
• A really well written article! The writing was very clear and it was packed with information. Great job! My corrections were knit-picky and a matter of opinion, so change things as you think…you’re the experts. ☺
  

Dehringb (talk) 21:34, 2 April 2014 (UTC)[reply]

MADE EDITS THROUGHOUT THE ARTICLE, THAT IS WHY IT IS PASTED BELOW.

2-Butoxyethanol is an organic compound whose molecular formula BuOC₂H₄OH (Bu = CH₃CH₂CH₂CH₂)classifies it as a butyl ether. This colorless liquid has a sweet, ether-like odor as it derives from the family of glycol ethers, such as ethylene glycol. As a relatively nonvolatile, inexpensive solvent it is used in many domestic and industrial products.

This article contains a lot of information about what 2-Butoxyethanol is used in and regulations put in place to limit the amount of the chemical in the environment. It is well organized but it feels like it's missing some information. The introduction doesn't really explain what the chemical does, just what it is. In order to have a better idea about how it is harmful to humans/the environment there might want to be some mention of what the role 2-Butoxyethanol plays in the products in which it is found. There is also not a lot of information about the effects that it has on humans. While it is difficult to find studies about human exposure to chemicals, it would be interesting to hear if there is any crossover between what happens to animals and humans when they are exposed to the chemical. It is clear that there are high levels of exposure found in industrial settings and that exposure does cause respiratory issues among other things, but how does the chemical cause those problems? Aukere (talk) 00:49, 3 February 2015 (UTC)[reply]

I thought this article was both really informative and well-organized! One area that I think would be interesting to elaborate more on is the use of 2-Butoxyethanol as a direct/indirect food additive. It is mentioned twice in the article, but gives relatively brief parallel information both times. Tiernestep (talk) 00:30, 3 February 2015 (UTC)[reply]

2-butoxyethanol is commonly obtained through two processes; the ethoxylation reaction of butanol and ethylene oxide in the presence of the catalyst

C₂H₄O + C₄H₉OH → C₄H₉OC₂H₄OH

or the etherification of butanol with 2-chloroethanol.<ref name=HHS>{{cite book|title=Toxicological Profile for 2-Butoxyethanol and 2-butoxyethanol acetate|date=August 1998|publisher=U.S. Dept of Health and Human Services|author=Harris O., et al}}</ref>

2-Butoxyethanol has modest surfactant properties. Glycol ethers have been used since the 1930s dissolve both water soluble and hydrophobic substances. Glycol ethers are also comprised of an alcohol from either the ethylene (E) series or the propylene (P) series. Glycol ethers are selected for specific purposes, such as solubility, inflammability, and volatility.<ref>{{cite web|last=Elskamp|first=Carl J.|title=2-Butoxyethanol (Butyl Cellosolve) & 2-Butoxyethyl Acetate (Butyl Cellosolve Acetate)|url=https://www.osha.gov/dts/sltc/methods/organic/org083/org083.html|publisher=United States Department of Labor}}</ref> In 2006, the European production of butyl glycol ethers amounted to 181 kilotons, of which approximately 50% (90 kt/a) was 2-butoxyethanol. World production is estimated to be 200 to 500 kt/a, of which 75% is for paints and coatings<ref name=Ullmann/> and 18% for metal and household cleaners.<ref name="Ethylene Glycol Mono-N-Butyl Ether">{{cite web|title=Ethylene Glycol Mono-N-Butyl Ether|url=http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~0Bg03b:1|publisher=National Library of Medicine|accessdate=2014-03-26}}</ref> In the US, it is considered a High Production Volume Chemical because more than 100 million pounds of this chemical are produced per year.<ref name="Ethylene Glycol Mono-N-Butyl Ether"/>

2-Butoxyethanol was introduced into the industrial industry as a solvent for paints and surface coatings, as well as cleaning products and inks. Other products that contain 2-butoxyethanol include acrylic resin formulations, asphalt release agents, firefighting foam, leather protectors, oil spill dispersants, degreaser applications, photographic strip solutions, whiteboard cleaners, liquid soaps, cosmetics, dry cleaning solutions, lacquers, varnishes, herbicides, latex paints, enamels, printing paste, varnish removers, and silicone caulk. Products containing this compound are commonly found at construction sites, automobile repair shops, print shops, and facilities for sterilizing and cleaning.<ref name="toxnet.nlm.nih.gov">{{cite web|title=Ethylene Glycol Mono-N-Butyl Ether|url=http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f?./temp/~4vgB71:1|publisher=National Library of Medicine HSDB|accessdate=2014-03-14}}</ref><ref name=SFGate2007>{{cite news | title = Hazard warning on home cleaners: Study says many use chemicals linked to fertility problems | author = Jane Kay | date = 2007-07-24 | url = http://www.sfgate.com/cgi-bin/article.cgi?file=/c/a/2007/07/24/HAZARDS.TMP&tsp=1 | publisher = [[San Francisco Chronicle]]| accessdate= 23 February 2008 <!--DASHBot-->| archiveurl= http://web.archive.org/web/20080228222443/http://www.sfgate.com/cgi-bin/article.cgi?file=/c/a/2007/07/24/HAZARDS.TMP&tsp=1| archivedate= 28 February 2008| deadurl= no}}</ref><ref>{{cite web | title = Potential Hazards of Home Cleaning Products | publisher = Women's Voices for the Earth | author = Alexandra Gorman | url = http://www.womenandenvironment.org/campaignsandprograms/SafeCleaning/HazardsReport.pdf | accessdate= 24 July 2007 <!--DASHBot-->}}</ref> Since it has both a non-polar and a polar end, it is the main ingredient of many home, commercial and industrial cleaning solutions to remove non-polar substances like grease and oils. The FDA has approved its use in the United States as a direct and indirect food additive, an antimicrobial agent, a defoamer, a stabilizer, and an adhesive.<ref name="Dickey">{{cite journal|last=Dickey|first=Robert|author2=W. Dickhoff|title=Assessment of the potential impact of COREXIT® oil dispersants on seafood safety|journal=Dispersants and Seafood Safety|url=http://www.crrc.unh.edu/sites/crrc.unh.edu/files/dickeydickhoff.pdf|accessdate=2014-03-26}}</ref> Butoxyethanol is a component of fracturing fluids, drilling stabilizers, and oil slick dispersants for both water-based and oil-based hydraulic fracturing in the petroleum industry<ref name="toxnet.nlm.nih.gov"/> Fracturing fluids pumped into wells under extreme pressure are stabilized with 2-Butoxyethanol, lowering the surface tension and preventing congealing to facilitate oil release.<ref name="toxnet.nlm.nih.gov"/> More general oil well workovers use it as a crude oil-water coupling solvent.<ref name="Ethylene Glycol Mono-N-Butyl Ether"/> 2-Butoxyethanol’s surfactant property is also a major constituent in dispersants for oil spills.<ref name="Dickey"/> One example is the dispersant Corexit 9527, used in the 2010 Deepwater Horizon oil spill<ref name="Dickey"/> , has incited controversy because of the possible its environmental and health effects. <ref name="Dickey"/>

Laboratory tests by the U. S. National Toxicology Program have shown that only sustained exposure to high concentrations (100-500 ppm) of 2-butoxyethanol can cause adrenal tumors in animals.<ref>{{cite web|title=Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS NO. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) |url=http://ntp.niehs.nih.gov/?objectid=070AC403-B110-CA79-3A23AF79DE7B752A|work=National Toxicology Program: Department of Health and Human Services|publisher=USA.gov|accessdate=4 June 2010| archiveurl= http://web.archive.org/web/20100528075034/http://ntp.niehs.nih.gov/?objectid=070AC403-B110-CA79-3A23AF79DE7B752A| archivedate= 28 May 2010 <!--DASHBot-->| deadurl= no}}</ref> Butoxyethanol has a low acute toxicity, with LD₅₀ of 2.5 g/kg in rats.<ref name=Ullmann>Siegfried Rebsdat, Dieter Mayer "Ethylene Oxide" in ''Ullmann's Encyclopedia of Industrial Chemistry'', Wiley-VCH, Weinheim, 2005.{{DOI|10.1002/14356007.a10_117}}.</ref> American Conference of Governmental Industrial Hygienists (ACGIH) reports that 2-butoxyethanol is carcinogenic in animals.<ref>{{cite web|title=Air Foam HD Material Data Safety Sheet|url=http://ia331209.us.archive.org/0/items/AirFoamHdMaterialDataSafetySheetmsds/|work=Product Safety|publisher=AquaClear, Inc|accessdate=4 June 2010}}</ref> However, due to the fact that cancer was primarily found in the forestomach which is absent in humans, these rodent tests may not translate directly to carcinogenicity in human beings. <ref>{{cite journal | author = Gift, J. S. | title = U.S. EPA's IRIS assessment of 2-butoxyethanol: the relationship of noncancer to cancer effects | journal = Toxicol. Lett. | year = 2005 | volume = 156 | pages = 163–178}}</ref> OSHA does not regulate 2-butoxyethanol as a carcinogen. ^{[citation needed]}

2-Butoxyethanol can be eliminated by incineration. While it usually decomposes in the presence of air within a few days when reacting with oxygen radicals <ref>Hullar, T.; Anastasio, C. Yields of hydrogen peroxide from the reaction of hydroxyl radical with organic compounds in solution and ice. Atmospheric Chemistry and Physics, 11, 7209.</ref> , disposal occurs faster in the presence of semiconductor particles.<ref name=HHS/> As there is no evidence to suggest it as a major environmental contaminant, nor is it known to bio-accumulate, it seems to be fairly manageable. <ref>[http://www.atsdr.cdc.gov/toxfaqs/tf.asp?id=346&tid=61 Agency for Toxic Substances and Disease Registry ToxFAQs]</ref>

Moderate respiratory exposure to 2-butoxyethanol often results in irritation of mucous membranes of the eyes, nose and throat. Heavy exposure via respiratory, dermal or oral routes can lead to hypotension, metabolic acidosis,<ref>{{cite journal|url=http://informahealthcare.com/doi/abs/10.3109/15563650.2010.492350|title=Fomepizole fails to prevent progression of acidosis in 2-butoxyethanol and ethanol coingestion|journal=Clinical Toxicology|date=2010-07|volume=48|number=6|pages=569–571|doi=10.3109/15563650.2010.492350}}</ref> hemolysis, pulmonary edema and coma.<ref name=Franks /> The current ACGIH threshold limit value (TLV) for worker exposure is 20 ppm in the industrial atmosphere, which is well above the odor threshold of 0.4 ppm. 2-Butoxyethanol is metabolized in animals by the enzyme alcohol dehydrogenase.<ref name=Franks>{{cite journal | author = Franks, S. J.; Spendiff, M. K.; Cocker, J.; Loizou, G. D. | title = Physiologically based pharmacokinetic modelling of human exposure to 2-butoxyethanol | journal = Toxicol. Lett. | year = 2006 | volume = 162 | pages = 164–173}}</ref> Blood or urine concentrations of 2-butoxyethanol or its major toxic metabolite, 2-butoxyacetic acid, can be detected using chromatographic techniques to monitor worker exposure and diagnose levels of toxicity in hospitalized patients. A biological exposure index of 200 mg 2-butoxyacetic acid per gram creatinine has been established in an end-of-shift urine specimen for exposed U.S. employees.<ref>''2009 TLVs and BEIs'', American Conference of Industrial Hygienists, Cincinnati, Ohio, 2009, p.101.</ref><ref>{{cite book | author = R. Baselt | title = Disposition of Toxic Drugs and Chemicals in Man | edition = 8th edition | publisher = Biomedical Publications | location = Foster City, CA | year = 2008 | pages = 208–210}}</ref> 2-Butoxyethanol and its metabolites fall to undetectable levels in urine after about 30 hours.<ref name=Franks />

After considerable scrutiny, the Environment and Health Canada recommended that 2-Butoxyethanol be added to Schedule 1 of the Canadian Environmental Protection Act (CEPA).<ref>{{cite web | title = Current Use Patterns in Canada, Toxicology Profiles of Alternatives, and the Feasibility of Performing an Exposure Assessment Survey | publisher = Environment Canada | url = http://www.chemicalsubstanceschimiques.gc.ca/fact-fait/butoxyethanol-eng.php | accessdate= 15 February 2011 <!--DASHBot-->}}</ref> These products are not required to list it on the label when diluted to a certain point. The safety of the products as normally used is defended by the American Chemistry Council and the Soap and Detergent Association, industry trade groups.

U.S. Employers are required to inform employees working with 2-Butoxyethanol.<ref>{{cite web | title = Glycol Ethers Fact Sheet | publisher = California Hazard Evaluation and Information Service | url = http://www.dhs.ca.gov/ohb/HESIS/glycols.htm | accessdate= 29 October 2007 <!--DASHBot-->}}</ref>

Butoxyethanol is listed in the U.S. state of California as a hazardous substance,<ref name="CALOSHA">{{cite web | url = http://www.dir.ca.gov/title8/339.html | title = California Code of Regulations, Title 8, Section 339. The Hazardous Substances List | accessdate= 2008-04-21 | publisher = State of California Department of Labor Relations | archiveurl= http://web.archive.org/web/20080505040711/http://www.dir.ca.gov/title8/339.html| archivedate= 5 May 2008 <!--DASHBot-->| deadurl= no}}</ref> though it was removed from the U.S. Environmental Protection Agency's list of hazardous air pollutants in 1994.<ref>{{cite web | publisher = [[U.S. Environmental Protection Agency]] | url = http://www.epa.gov/EPA-AIR/2004/November/Day-29/a26071.htm | date = 2004-11-29 | title = List of Hazardous Air Pollutants, Petition Process, Lesser Quantity Designations, Source Category List; Petition To Delist of Ethylene Glycol Monobutyl Ether| accessdate= 23 February 2008 <!--DASHBot-->}}</ref>

Potentially harmful effects have been observed in animals exposed to high levels of 2-butoxyethanol. One study exposing pregnant Fischer 344 rats and New Zealand white rabbits to varying doses of 2-butoxyethanol revealed lasting developmental effects A statistically significant increases in skeletal defects were detected in litters treated with 100 ppm (483 mg/m³) and 200 ppm (966 mg/m³). Additionally, 2-butoxyethanol was associated with a significant decrease in maternal body weight, uterine weight, and number of total implants.<nowiki><ref>Wess, Ms. J., Dr. H. Ahlers, and Dr. S Dobson. "Concise International Chemical Assessment Document 10: 2-Butoxyethanol." World Health Organization, n.d. Web. <http://www.who.int/ipcs/publications/cicad/cicad_10_revised.pdf></ref></nowiki>

Neurological effects were identified in one study involving 344 rats tested with 2-butoxyethanol at concentrations of 523 ppm and 867 ppm. Both female and male rats experienced decreased coordination after exposure. Similarly male rabbits in another study exhibited a loss of coordination and equilibrium when given a dose of 400 ppm 2-butoxyethanol for 2 days.<ref>United States of America. Agency for Toxic Substances and Disease Registry. Department of Health and Human Services. Toxicological Profile for 2-Butoxyethanol and 2-Butoxyethanol Acetate. By Olivia Harris, Sharon Wilbur, Julia George, and Carol Eisenmann. Atlanta: n.p., 1998. Agency for Toxic Substances and Disease Registry. Web. <http://www.atsdr.cdc.gov/toxprofiles/tp118.pdf></ref>

Both F344/N rats and B63F1 mice showed negative effects after 2-butoxyethanol in their drinking water. The range of exposure for the two species was between 70 mg/kg body weight per day to 1300 mg/kg body weight per day. Decreased body weight and water consumption were seen for both species. Rats had reduced red blood cell counts and thymus weights, as well as lesions in the liver, spleen, and bone marrow.<ref>Wess, Ms. J., Dr. H. Ahlers, and Dr. S Dobson. "Concise International Chemical Assessment Document 10: 2-Butoxyethanol." World Health Organization, n.d. Web. <http://www.who.int/ipcs/publications/cicad/cicad_10_revised.pdf>.</ref>

Some modifications that I made throughout the page include:

• Replacing sentences that begin with “It”

• Combining short sentences

• Eliminating repetition

• Keep in mind to use an active voice, not a passive voice. Clearer and to the point in some cases. Passive voice with controversial points.

Uses:

• 18% for metals production or a metal cleaner?

• Facilities for sterilizing and cleaning=sterilizing and cleaning facilities or = used to sterilize and clean at facilities?

Safety

• Observed “mechanism” (right word?/slightly confusing)

• OSHA does not regulate 2-butoxyethanol as a carcinogen.[citation needed]

Disposal

• Semiconductor particles-link

Human Exposure

• Odor threshold of 0.4ppm, what is that?

Regulation in Canada

• What is schedule 1?

• What list of products are you referring to?

• Are butoxyethanol and 2-Butoxyethanol the same thing?

Animal Studies

• Study by Ty et al. or Dodd et al seems very strange, would not make sense to the normal reader. Who is he/are they?

• Some of the smaller paragraphs have a few sentences with one reference at the end of the paragraph. Was that one reference a citation for each sentence, if so, make sure that is the proper format as I was not sure

• What exactly is meant by range of exposure? Amount of chemical retained afterwards?

Environmental Fate: REPEAT of information from disposal section/not needed

• butoxyethanol degrades in air within a few days or weeks.<ref name=WHO>{{cite book|title=Concise International Chemical Assessment Document 10: 2-Butoxyethanol|year=1998|publisher=World Health Organization|location=Geneva|author=Wess, J.|author2=Ahlers, H.|author3= Dobson, S.}}</ref> It has not been identified as a major environmental contaminant, nor is it known to bio-accumulate.- wikilink with first reference in article as this is the second time and do not need to create link if already done so, even if a specific word or phrase is mentioned again

I read through your article and found that it was well done. I made edits throughout in this version where I thought that they could prove helpful although you are free to take or leave any input here. I tried to be as constructive as possible in my criticism. I would find another way to mention the example studies instead of by author as the average reader would care less about what some random scientist says. If he or she has a specific title, then mention it; if not, then make it more general: “A study or one study.” That draws more attention to the study rather than unknown researchers. There was a good overall flow and it was relatively clear although there were some parts where I was a littler uncertain as to what was being referenced. The citations seem to be in check, aside from one or two spots where it was shown to be needed already. (Wess, J.; Ahlers, H.; Dobson, S. (1998). Concise International Chemical Assessment Document 10: 2-Butoxyethanol. Geneva: World Health Organization.) was cited 2 or 3 times in the reference section. Find a way so that your multiple in-text citations for the same source refer to the same one in your reference list. This article appears to be pretty neutral as far as just stating the facts but the end seems to favor the side that it is harmful. Show evidence from both sides of the studies or at least take a more passive stance when revealing conclusions. You have a lot of great headings, but look to make your leading sentence more interesting. It seemed a little repetitive at first and it could have been worded better. Add some more general information Looks to have a fair amount of information added though, so good work! I especially like the USES section. Maybe work to expand the global opinions on this chemical, since only Canada and the US are mentioned. Make it more international. Overall, again well done and I hope some of this was helpful. WlfSprtd23--WlfSprtd23 (talk) 11:02, 11 April 2014 (UTC)[reply]

Dear WlfSprtd23: What qualifies you to state "I read through your article and found that it was well done." ? Do you publish in this area?--Smokefoot (talk) 14:30, 11 April 2014 (UTC)[reply]

The edits made are as follows:

• Reworked the intro to not start sentences with "it"
• Reworked the production section in order to make it sound better
• Moved the paragraph on production in the "Uses" section to the "Production" section
• Added clarity to a few confusing sentences in the "Uses" section, as suggested
• Split the "Uses" section into subheadings by industry for more organization
• Made sure that the in-text citations that referred to the same source were directed to one source in the "References" section
• Added a link to the odor detection threshold wikipedia page in order to avoid confusion about the definition of that term
• Reworded the "Regulation in Canda" section to avoid confusing wording and lack of antecedents for pronouns
• Added a link to the "laboratory rats" wikipedia page after mentioning Fisher 344 rats in the animal studies section, in order to avoid confusion
• Removed the "environmental fate" since it was a repeat from "disposal" section
• Changed the order of the animal studies and regulation sections to make more sense, as suggested
• Found a citation for the sentence on OSHA not regulating 2-butoxyethanol.

The edits that were not made:

Didn't define .4ppm in the Human exposure section, Schedule 1 in the Regulation in Canda section and didn't change the use of Ty et al. and Dodd et al. in the Animal Studies section. We believe that these are very common terms and don't need to be defined or changed.

"BUTOXYETHANOL." || Skin Deep® Cosmetics Database. N.p., n.d. Web. <http://www.ewg.org/skindeep/ingredient/700842/BUTOXYETHANOL/>.

Committee on Energy and Commerce Minority Staff. "Chemicals Used in Hydraulic Fracturing." United States House of Representatives, n.d. Web. <http://democrats.energycommerce.house.gov/sites/default/files/documents/Hydraulic-Fracturing-Chemicals-2011-4-18.pdf>.

"Investigation Yields List of Chemicals Used in Fracking; Many Are Known Carcinogens, Regulated Pollutants." Frack Check WV RSS. N.p., n.d. Web. 17 Feb. 2014. <http://www.frackcheckwv.net/2011/04/17/investigation-yields-list-of-chemicals-used-in-fracking-many-are-known-carcinogens-regulated-pollutants/>.

"Ethylene Glycol Monobutyl Ether (EGBE)(2-Butoxyethanol) (CASRN 111-76-2)."Integrated Risk Information System. United States Environmental Protection Agency, n.d. Web. <http://www.epa.gov/iris/subst/0500.htmxe>.

Kirby, David. "Corexit: An Oil Spill Solution Worse Than the Problem?."TakePart. Participant Media, 22 Apr. 2013. Web. 17 Feb. 2014. <http://www.takepart.com/article/2013/04/17/corexit-deepwater-horizon-oil-spill>.

Nikiforuk, Andrew. "The Tyee – Birth Defects Linked to Natural Gas Mining."The Tyee. N.p., 4 Feb. 2014. Web. 17 Feb. 2014. <http://thetyee.ca/News/2014/02/04/Natural-Gas-Mining-Birth-Defects/>.

Wess, Ms. J., Dr. H. Ahlers, and Dr. S Dobson. "Concise International Chemical Assessment Document 10: 2-Butoxyethanol." World Health Organization, n.d. Web. <http://www.who.int/ipcs/publications/cicad/cicad_10_revised.pdf>.

United States of America. Agency for Toxic Substances and Disease Registry. Department of Health and Human Services. Toxicological Profile for 2-Butoxyethanol and 2-Butoxyethanol Acetate. By Olivia Harris, Sharon Wilbur, Julia George, and Carol Eisenmann. Atlanta: n.p., 1998. Agency for Toxic Substances and Disease Registry. Web. <http://www.atsdr.cdc.gov/toxprofiles/tp118.pdf>.

Blairwal (talk) 21:04, 17 February 2014 (UTC) Kglobalhealth (talk) 21:04, 17 February 2014 (UTC) Custodim (talk) 21:05, 17 February 2014 (UTC)[reply]

Thanks for consulting the Talk page. Two comments/suggestions:

• On what basis did you select the sources above? Approximately 9939 publications and patents describe butoxyethanol. Here are some real reviews (see WP:SECONDARY:
  • Meeting Report: Summary of IARC monographs of formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol

By Cogliano, Vincent James; Grosse, Yann; Baan, Robert A.; Straif, Kurt; Secretan, Marie Beatrice; El Ghissassi, Fatiha; Andrae, Ulrich; Burge, Sherwood; Chhabra, Rajendra; Cocker, John; et al

From Environmental Health Perspectives (2005), 113(9), 1205-1208.

• • Assessing the toxic effects of ethylene glycol ethers using Quantitative Structure Toxicity Relationship models

By Ruiz, Patricia; Mumtaz, Moiz; Gombar, Vijay

From Toxicology and Applied Pharmacology (2011), 254(2), 198-205.

• • INRS activities on risk assessment of glycol ethers

By Fastier, A.; Herve-Bazin, B.; McGregor, D. B.

From Toxicology Letters (2005), 156(1), 59-76.  

• Wikipedia is international. Your sources appear to be very US-centered.
• --Smokefoot (talk) 05:02, 18 February 2014 (UTC)[reply]

Hello, I am a student enrolled in course Environmental Disruptors/Development at BC. As an assignment, we are going around leaving some comments in articles that were worked on in previous courses. ◌For Human Exposure section I found some related information that could have been included and expand the section. That most people start to smell the chemical in air at 0.10-0.40 ppm which is 500 times lower than the present standard for worker exposure. <ref>http://www.atsdr.cdc.gov/phs/phs.asp?id=345&tid=61</ref> Including that household cleaners like varnishes, lacquers, latex paints as common source of the chemical in this section might help the readers grasp the info that they need quicker. But I am aware that you included such information up on "commercial uses" section. More information on how it enters and leaves one's body might be useful. That the exposure is less likely through eating or drinking but more from breathing in air (through the lung)-also the fact that wearing protective clothing decreases the entrance through skin. The reaminder of butoxyethanol enters the bloodstream possibly causing being converted into metabolites in the liver. If you want more information visit http://www.atsdr.cdc.gov/phs/phs.asp?id=345&tid=61 Thank you for all your work! Jukaredaa (talk) 06:24, 3 February 2015 (UTC)[reply]

Please use good sources: published reviews and textbooks. Avoid Google searching! You are welcome to ask for advice! This article is a mature one, and it would be surprising if a nonexpert could make major contributions. Good luck.--Smokefoot (talk) 14:43, 3 February 2015 (UTC)[reply]

The page currently lists the GHS classification of this material as:

H227, H302, H311, H315, H319, H330, H336, H361, H370, H372

This does match the description of the text which claims a "Low acute toxicity" and also does not match the harmonised classification or the ECHA dossier for the material, which classifies it as:

H302, H312, H315, H319, H332, Signal word: WARNING (GHS07)

The classification that is currently used in the page is similar to 2-methoxyethanol and 2-ethoxyethanol, it makes sense that either one of these classifications was used in error or the SDS used to derive the given classification was for a product containing material of a more severe classification.

If people agree with this assessment then I will happily make the modifications to the page. — Preceding unsigned comment added by 151.249.75.66 (talk) 10:24, 29 August 2017 (UTC)[reply]