Take the Money and Run may refer to:

• "Take the Money and Run" (Bunny Walters song), 1972
• "Take the Money and Run", by Crosby & Nash from Wind on the Water, 1975
• "Take the Money and Run" (Steve Miller Band song), 1976
• "Take the Money and Run", by Gerry Rafferty from Night Owl, 1979
• "Take the Money and Run", by Alan Parsons from Alan Parsons Live, 1994
• "Solo Impala (Take the Money and Run)", by the Fashion from The Fashion, 2007
• "Take the Money and Run", by Michael Nyman and David McAlmont from The Glare, 2009
• "Take the Money and Run" (O'G3NE song), 2016

• Take the Money and Run (film), a 1969 comedy film by Woody Allen
• Take the Money and Run (TV series), a 2011 American reality game show
• "Take the Money and Run" (CSI: Crime Scene Investigation), an episode

• Take the Money and Run (artwork), 2021 work by Jens Haaning