Protein-coding gene in the species Homo sapiens
Tripartite motif-containing protein 15 is a protein that in humans is encoded by the TRIM15 gene .[ 5] [ 6] [ 7] [ 8]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family . The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Its function has not been identified. Alternate splicing of this gene results in two transcript variants encoding different isoforms.[ 8]
References
^ a b c ENSG00000227147, ENSG00000233599, ENSG00000204610, ENSG00000224145, ENSG00000235905, ENSG00000137384, ENSG00000235259 GRCh38: Ensembl release 89: ENSG00000235960, ENSG00000227147, ENSG00000233599, ENSG00000204610, ENSG00000224145, ENSG00000235905, ENSG00000137384, ENSG00000235259 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050747 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments" . EMBO J . 20 (9): 2140– 51. doi :10.1093/emboj/20.9.2140 . PMC 125245 PMID 11331580 . ^ Goei VL, Parimoo S, Capossela A, Chu TW, Gruen JR (Mar 1994). "Isolation of novel non-HLA gene fragments from the hemochromatosis region (6p21.3) by cDNA hybridization selection" . Am J Hum Genet . 54 (2): 244– 51. PMC 1918154 PMID 8304341 . ^ Gruen JR, Nalabolu SR, Chu TW, Bowlus C, Fan WF, Goei VL, Wei H, Sivakamasundari R, Liu Y, Xu HX, Parimoo S, Nallur G, Ajioka R, Shukla H, Bray-Ward P, Pan J, Weissman SM (Feb 1997). "A transcription map of the major histocompatibility complex (MHC) class I region" . Genomics . 36 (1): 70– 85. doi :10.1006/geno.1996.0427 PMID 8812418 . ^ a b "Entrez Gene: TRIM15 tripartite motif-containing 15" .
Further reading
Shiina T, Ota M, Shimizu S, et al. (2006). "Rapid Evolution of Major Histocompatibility Complex Class I Genes in Primates Generates New Disease Alleles in Humans via Hitchhiking Diversity" . Genetics . 173 (3): 1555– 70. doi :10.1534/genetics.106.057034 . PMC 1526686 PMID 16702430 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions" . Genome Res . 14 (9): 1711– 8. doi :10.1101/gr.2435604 . PMC 515316 PMID 15342556 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Harada H, Harada Y, O'Brien DP, et al. (1999). "HERF1, a Novel Hematopoiesis-Specific RING Finger Protein, Is Required for Terminal Differentiation of Erythroid Cells" . Mol. Cell. Biol . 19 (5): 3808– 15. doi :10.1128/MCB.19.5.3808 . PMC 84222 PMID 10207104 .
