A technical knockout (TKO) is a professional fighting term.

TKO may also refer to:

• TKO, the name of a professional wrestling move referring to either the cutter or stunner variant
• TKO Group Holdings, a combat sports company

• TKO (band), a rock band from Seattle, Washington
• TKO, a pop group led by Katie White

• TKO (Tsakani Mhinga album), 2000
• TKO (The Knock Out), 2018 album by Mýa
• TKO, album by Kelly Khumalo, 2005

• "TKO" (Justin Timberlake song), 2013
• "TKO" (Le Tigre song), 2004
• "TKO" (Motion City Soundtrack song), 2015
• "TKO (Knock You Out)", by Bubbles, 2003
• "TKO", from Bassnectar's Unlimited, 2016
• "TKO", from Jesse Malin's The Fine Art of Self Destruction, 2002
• "TKO", from the Sam & Max Season Two Soundtrack
• "T.K.O.", by Giant Panda, 2005
• "T.K.O.", from Womack & Womack's debut album Love Wars, 1983
• "T.K.O. (Boxing Day)", from Elvis Costello's Punch the Clock, 1983
• "T.K.O.", from Dave Grusin's Migration, 1989

• "TKO" (Babylon 5), an episode of the TV series Babylon 5
• T.K.O. (film), a 2007 film starring Dianna Agron
• The Kill Order, the prequel novel to The Maze Runner series
• Three Kingdoms Online, a browser based strategy game
• TKO: Total Knock Out, an obstacle course reality TV game show
• T.K.O., an OK K.O.! Let's Be Heroes character

• Taylor KO Factor, a measurement of the stopping power of a firearms cartridge
• TKO Software, a defunct software company
• Triple knockout, in molecular biology
• "To keep open", a medical acronym for an intravenous drip that is flowing just enough to keep the IV open for future use (sometimes written as KVO—"keep vein open")

• The Kindness Offensive, a North London group known for random acts of kindness
• Tie knock out, a railroad maintenance vehicle also known as a tie extractor
• Tseung Kwan O, a new town in Hong Kong
  • MTR station code for Tseung Kwan O station
• Station code for Taman Kota railway station in West Jakarta, Indonesia
• TKO Studios, a comics publisher

• "Love T.K.O.", a 1980 song written by Cecil Womack, mainly associated with Teddy Pendergrass
• KO (disambiguation)
• Knockout (disambiguation)