Sykes may refer to:

• Sir Alan Sykes, 1st Baronet, businessman and British politician
• Annette Sykes, New Zealand human rights lawyer and Māori activist
• Bob Sykes (American football), American football player
• Bob Sykes (baseball), American baseball pitcher
• Bob Sykes (ice hockey), Canadian ice hockey player
• Bobbi Sykes, Australian author and land rights activist
• Bryan Sykes, British academic and geneticist
• Christopher Sykes (author), British author
• Christopher Sykes (politician), British politician
• Diane S. Sykes, judge on the United States Court of Appeals
• Edmund Sykes, Catholic martyr
• Emilia Sykes, American politician
• Eric Sykes, comedic writer and actor
• Eric A. Sykes, developer of the Fairbairn-Sykes fighting knife
• Ernest Sykes (VC), recipient of the Victoria Cross
• Ernest Ruthven Sykes (1867–1954), malacologist from Great Britain
• Eugene O. Sykes (1876–1945), justice on the Mississippi Supreme Court
• Frederick Henry Sykes (1863–1917), Canadian-American educator and college president
• Sir Frederick Hugh Sykes, British military officer and politician
• Gary Sykes, English Profesional boxer
• George Sykes, U.S. Army general
• Gresham Sykes (1922–2010), American sociologist and criminologist
• Homer Sykes, Canadian-born British photographer
• Congressman James Sykes (Continental Congress), lawyer and American politician
• Governor James Sykes (governor), physician and American politician
• John Sykes, rock musician
• John Sykes (American football) (1949–2019), American football player
• John Sykes (composer) (1909–1962), English composer and music teacher, born in India
• John Sykes (politician), British politician
• John H. Sykes Tampa Bay area businessman and founder of Sykes inc.
• Keifer Sykes (born 1993), American basketball player
• Sir Mark Sykes, British politician and diplomatic advisor
• Melanie Sykes (born 1970), English television and radio presenter, and model
• Nathan Sykes (born 1993), member of boy band The Wanted
• Norman Sykes (1936–2009), English footballer
• Oliver Sykes, frontman of Bring Me the Horizon
• Paul Sykes (boxer) (1946–2007), English heavyweight boxer of the 1970s and 1980s
• Paul Sykes (businessman) (born 1943), English Eurosceptic businessman, and political donor
• Paul Sykes (rugby league) (born 1981), rugby league footballer of the 1990s, 2000s and 2010s
• Paul Sykes (singer), American folksinger of the 1960s
• Sir Percy Sykes, British soldier, geographer and travel writer
• Peter Sykes (director) (1939–2006), Australian/British film director
• Peter Sykes (chemist) (1923–2003), British chemist
• Sir Richard Sykes (biochemist), businessman and university rector
• Sir Richard Sykes (diplomat), diplomat assassinated in 1979
• Richard Sykes (rugby union), Rugby player and Dakota landowner
• Rod Sykes (1929–2025), Canadian politician from Alberta
• Stephen Sykes, ecclesiologist
• Sykes family of Sledmere
• Tatton Sykes (disambiguation)
• Thomas Sykes (Mississippi politician), African-American legislator in Mississippi during Reconstruction
• Thomas A. Sykes, African-American legislator in North Carolina and Tennessee during Reconstruction
• Thomas Hardcastle Sykes, businessman
• Timothy Sykes (born 1981), penny stock trader
• Tom Sykes, British motorcycle racer
• Wanda Sykes, comedian and actress
• William Sykes (1852–1910), English businessman
• Colonel William Henry Sykes, military officer, politician, and ornithologist
• William Robert Sykes, British railway signal engineer

• Sykes Bleaching Company
• Sykes Enterprises, Incorporated, a family of global companies delivering business process outsourcing services

• Bill Sykes, antagonist from the animated Disney film Oliver & Company
• Fredrick Sykes, one of the main antagonists of the 1993 action film The Fugitive
• Mr. Sykes, a character from the film Shark Tale, voiced by Martin Scorsese
• Sgt. Michael "Psycho" Sykes, the main character in the game Crysis Warhead, and a secondary character in Crysis
• Reverend Sykes, a character from Harper Lee's novel To Kill a Mockingbird
• Robert "Pliers" Sykes, character in the game Wing Commander IV

• Sykes, Lancashire, England
• Sykesville, Maryland, USA
• Forward Operating Base Sykes, a U.S. military base in Iraq
• Sykes Camp, a campground in California

• 4438 Sykes, an asteroid
• Sykes (dog), a dog actor from Clifton, Oxfordshire, England
• Sykes (TV series), a British sitcom that aired on BBC 1 from 1972 to 1979
• Sykes baronets, four separate baronetcies of Great Britain or the United Kingdom

• Sikes (disambiguation)
• Syke (disambiguation)
• All pages with titles containing Sykes