Sweetleaf may refer to:

• Sauropus androgynus, a plant of the family Phyllanthaceae whose leaves may be used as a potherb
• Stevia, a genus of plants in the family Asteraceae whose leaves may be used for sweetening
• SweetLeaf Living Foods, an Australian Tea Company based in Kuranda, Queensland
• "Sweet Leaf", a song by Black Sabbath
• Sweet Leaf Tea Company, US manufacturer of prepared tea drinks
• Symplocos tinctoria, an evergreen shrub or small tree in the southeastern United States
• Monarda fistulosa, a medicinal and ornamental herb
• Slang term for Cannabis