Strain may refer to:

• Strain (biology), variants of biological organisms
• Strain (chemistry), a chemical stress of a molecule
• Strain (injury), an injury to a muscle
• Strain (mechanics), a measure of deformation
• Filtration, separating fluids from solids by passing through a filter
• Percolation, of fluids through porous materials
• Psychological stress

• straining, in cooking, by a strainer or sieve.
• Strain, a term in contract bridge

• Strain (surname)

• Strain (manga), 1996
• Strain (music), phrases of a piece
• Strain (album), 2004, by Flesh Field
• Strain: Strategic Armored Infantry, a 2006 anime
• Strain (film), a 2020 Nigerian drama

• Strain, Arkansas, US, an unincorporated community
• Strain, Missouri, US, an unincorporated community

• Overwork
• S Train (disambiguation)
• Strain theory (disambiguation)
• Strainer
• The Strain (disambiguation)
• Stressor