Spens or SPENS may refer to:

• Clan Spens, a kindred from the Scottish Lowlands
• Baron Spens, a title in the Peerage of the United Kingdom
• Spens (musician), Bulgarian hip-hop artist
• Janet Spens, Scottish academic
• Sir Patrick Spens, an early Scottish Ballad
• Patrick Spens, 1st Baron Spens, British lawyer, judge and Conservative politician
• Will Spens, Cambridge academic and educationist
• Sir James Spens / friherre Jacob Spens; Scottish adventurer, soldier and diplomat, and the first Swedish Baron Spens

• Spens clause, a mechanism for adjusting the redemption price of a bond on early repayment
• SPC Vojvodina, commonly known as SPENS, a multi-purpose venue in Novi Sad, Serbia

• Spence (disambiguation)