Speiser is a German and Yiddish surname. Notable people with the surname include:

• Ambros Speiser (1922–2003), Swiss engineer and scientist
• Andreas Speiser (1885–1970), Swiss mathematician
• Elisabeth Speiser (born 1940), Swiss operatic soprano
• Eliyahu Speiser (1930–2009), Israeli politician
• Ephraim Avigdor Speiser (1902–1965), American Assyriologist
• Felix Speiser (1880–1949), Swiss ethnologist
• Jerry Speiser (born 1953), Australian drummer
• Markus Speiser (born 1985), Austrian footballer
• Paul Gustav Eduard Speiser (1877–1945), German entomologist
• Paul Speiser (1846–1935), Swiss politician

• All pages with titles containing Speiser
• Speiser Shale, a geologic formation in Kansas, United States
• Speiser v. Randall, a United States Supreme Court case