Soulsby may refer to:

• Ben Soulsby, lumbermill owner and founder of Soulsbyville, California, USA
• Heidi Soulsby, British politician from Guernsey
• Henry Soulsby, builder of the 1926 Soulsby Service Station on U.S. Route 66 in Mount Olive, Illinois.
• James Soulsby (1897–1980), English footballer
• Lawson Soulsby, Baron Soulsby of Swaffham Prior (1926–2017), British microbiologist and parasitologist
• Sir Peter Soulsby (born 1948), British politician, Mayor of Leicester
• Sir William Soulsby (1851–1937), English barrister, Private Secretary to the Lord Mayor of London