Sir Nathaniel Curzon, 4th Baronet (1676–1758), of Kedleston Hall, Derbyshire, was an English Tory politician who represented three constituencies in the 18th century.^[1]

Curzon was the son of Sir Nathaniel Curzon, 2nd Baronet, of Kedleston, and his wife Sarah Penn, daughter of William Penn of Penn, Buckinghamshire.^[2]

Curzon was elected as Member of Parliament for Derby in 1713, but lost the seat in 1715. He was then elected for Clitheroe in 1722. When his elder unmarried brother John died in 1727, he inherited the baronetcy and Kedleston Hall. In the 1727 general election he retained his brother's parliamentary seat for Derbyshire, which he held until 1754.

Curzon married Mary Assheton, daughter of Sir Ralph Assheton, 2nd Baronet, of Middleton, Lancashire. On Curzon's death in 1758, his elder son, Nathaniel, succeeded to the baronetcy and was later made Baron Scarsdale in 1761. His second son, Assheton, was made Baron Curzon in 1794 and later Viscount Curzon in 1802.