Sikandar is the Persian rendition of the name Alexander. When the Macedonian king Alexander the Great conquered Persia, the Persians called him Sikandar lidi, meaning "defender" or "warrior". It is a variant of Iskandar.

• Alexander the Great (BC 356–323), also known as Sikandar-i-Azam
• Alauddin Khalji (1266–1316), Sultan of Delhi, who minted coins using the title Sikandar-e-Sani (The Second Alexander)
• Sikandar Khan Ghazi (14th century), Vizier of Sylhet
• Abul Mujahid Sikandar Shah (died 1390), Sultan of Bengal
• Sikandar Shah Miri Butshikan (1353–1413), Sultan of Kashmir
• Sikandar Shah, Sultan of Bengal (1358–1390)
• Nuruddin Sikandar Shah (15th century), Sultan of Bengal
• Sikandar Khan Lodi (1458–1517), Sultan of Delhi
• Sikandar Shah of Gujarat, ruler of Gujarat Sultanate (died 1526)
• Sikandar Shah Suri (died 1559), Sultan of Delhi
• Sikander Jah, Asaf Jah III (1768–1829), Nizam of Hyderabad

• Sikandar Hayat Khan (1892–1942), politician in British India
• Sikandar Abu Zafar (1918–1975), Bangladeshi journalist and poet
• Sikander Bakht (1918–2004), Indian politician
• Sikander Bakht (born 1957), Pakistani cricketer
• Sikandar Kher (born 1982), Indian actor
• Sikandar Sultan, Pakistani businessman
• Sikandar Raza (born 1986), Pakistani-Zimbabwean cricketer.

• Secunderabad, a city in Telangana, India, named after Sikandar Jah
• Sekandar, Markazi, a village in Markazi Province, Iran
• Sikandar, Iran, a village in Sistan and Baluchestan Province, Iran
• Sikandar Bagh, a fortified villa and garden in Lucknow, India, a sepoy stronghold during the Indian Mutiny

• Sikandar (1941 film), an Indian film by Sohrab Modi about Alexander the Great
• Sikandar (2009 film), an Indian Hindi-language film directed by Piyush Jha
• Sikander, a 2013 Indian Punjabi-language film
  • Sikander 2, its sequel film by Manav Shah
• Sikandar (2025), an Indian Hindi-language film directed by AR Murugadoss

• Iskandar (disambiguation)
• İskender (disambiguation)
• Sikandarabad (disambiguation)
• Sikanderpur (disambiguation)