Santa Cruz (Spanish or Portuguese, 'holy cross') or Santacruz may refer to:

• Fort of Santa Cruz (Oran), a fort in Oran port city in Algeria
• Santa Cruz, Cape Verde, a municipality on the eastern part of the island of Santiago
• Santa Cruz do Cabo de Gué, the 16th-century name of Agadir, Morocco
• Santa Cruz (Santiago), a town on the island of Santiago, Cape Verde
• Santa Cruz, São Tomé and Príncipe, on São Tomé Island

• Santa Cruz Islands, Solomon Islands in the Pacific Ocean

• RAF Santa Cruz, a former Royal Air Force airfield, Mumbai
• Santacruz, Mumbai, Maharashtra
• Santacruz Airport, the domestic terminal of Chhatrapati Shivaji Maharaj International Airport
• Santacruz metro station, Mumbai
• Santacruz railway station, railway station on the Mumbai suburban railway
• Santa Cruz, Goa, a suburb of the state capital of Panjim

• Santa Cruz (Almodôvar), civil parish in the municipality of Almodôvar
• Santa Cruz (Coimbra), civil parish in the municipality of Coimbra
• Santa Cruz, Madeira, municipality on the island of Madeira
• Santa Cruz (Praia da Vitória), a civil parish on Terceira Island, Azores
• Santa Cruz (Armamar) [pt], civil parish in Armamar
• Santa Cruz (Santiago do Cacém) [pt], former civil parish in Santiago do Cacém
• Santa Cruz (Torres Vedras), village and beach resort in the parish of Silveira
• Santa Cruz (Vinhais) [pt], civil parish in the municipality of Vinhais

• Santa Cruz (Lagoa), civil parish in the municipality of Lagoa
• Santa Cruz das Flores, municipality on the island of Flores
  • Santa Cruz das Flores (parish), civil parish in the municipality of Santa Cruz das Flores
• Santa Cruz da Graciosa, municipality on the island of Graciosa
  • Santa Cruz da Graciosa (parish), civil parish in the municipality of Santa Cruz da Graciosa

• Province of Santa Cruz de Tenerife, containing the islands of Tenerife, La Gomera, El Hierro, and La Palma
• Santa Cruz, an urban area in Oleiros, Galicia
• Santa Cruz (Mieres), a parish in Mieres, Asturias
• Santa Cruz, Seville, city district
• Castillo de Santa Cruz, castle on the Isla de Santa Cruz in A Coruña, Galicia
• Santa Cruz de Tenerife, capital of the Province of Santa Cruz de Tenerife and joint capital of the Canary Islands
• Santa Cruz del Valle de los Caídos, basilica and monument in the Sierra de Guadarrama, near Madrid

• Santa Cruz (canton), Costa Rica, in Guanacaste Province, Costa Rica
• Santa Cruz del Quiché, city in Guatemala
• Santa Cruz, Lempira, a municipality in the department of Lempira, Honduras
• Santa Cruz de Yojoa, municipality in Honduras
• Santa Cruz, Jamaica, town in St. Elizabeth Parish, Jamaica
• Santa Cruz, Trinidad and Tobago, town in the Santa Cruz Valley, Trinidad and Tobago

• Santa Cruz, Orange Walk, a municipality in Belize
• Santa Cruz, Stann Creek, municipality
• Santa Cruz, Toledo, village in Toledo District

• Santa Cruz, Ontario, an underwater ghost town

• Santa Cruz del Norte, town and municipality in the Mayabeque Province
• Santa Cruz del Sur, town and municipality in the Camagüey Province

• Santa Cruz de Barahona, city in the Barahona Province
• Santa Cruz de El Seibo, city in the El Seibo Province
• Santa Cruz de Mao, municipality in the Valverde province

• Santa Cruz, Aruba, town in central Aruba
• Playa Santa Cruz, beach on the Caribbean island of Curaçao

• Santa Cruz Atizapán, town and municipality in Mexico State
• Santa Cruz de Juventino Rosas, city and municipality in Guanajuato
• Santa Cruz del Rincón, municipality in Guerrero
• Santa Cruz Municipality, Sonora
  • Santa Cruz, Sonora, town in Santa Cruz Municipality

• Santa Cruz, Rivas, village on the island of Ometepe in Lake Nicaragua
• Santa Cruz, Rio San Juan, village in El Castillo, Nicaragua

• Santa Cruz, Renacimiento, corregimiento in Renacimiento District, Chiriquí Province
• Santa Cruz, San Félix, corregimiento in San Félix District, Chiriquí Province

• Santa Cruz, Carolina, Puerto Rico, a barrio

• Santa Cruz, Chile, city and commune in the O'Higgins Region
• Santa Cruz, Aragua, city and part of the metropolitan area of Maracay, Venezuela

• Santa Cruz Province, Argentina, in Patagonia
  • Puerto Santa Cruz, town and municipality in Santa Cruz province
• Santa Cruz, Catamarca, village and municipality
• Santa Cruz, La Rioja, village and municipality
• Santa Cruz River (Argentina), in Santa Cruz province

• Santa Cruz Department (Bolivia)
  • Santa Cruz de la Sierra, capital city of Santa Cruz Department

• Santa Cruz, Pernambuco, city in the state of Pernambuco
• Santa Cruz da Baixa Verde, city in the state of Pernambuco
• Santa Cruz do Capibaribe, city in the state of Pernambuco
• Santa Cruz do Sul, city in Rio Grande do Sul

• Santa Cruz, Rio de Janeiro, neighborhood in Rio de Janeiro
• Santa Cruz (São Paulo Metro), metro station in the Vila Mariana district of São Paulo

• Santa Cruz de Mompox, town and municipality in the Bolívar Department
• Santa Cruz del Islote, island in the Caribbean Sea, part of the Archipelago of San Bernardo
• Santacruz, Nariño, town and municipality
• Santa Cruz (Medellín), commune in the city of Medellín

• Santa Cruz Canton, Ecuador, canton in the province of Galápagos
• Santa Cruz Island (Galápagos), one of the Galápagos Islands

• Santa Cruz (surname), list of notable people bearing this name

• Santa Cruz Beach Boardwalk, oceanfront amusement park, Santa Cruz, California
• Santa Cruz Bicycles, American bicycle manufacturer
• Santa Cruz Games, video game company
• Santa Cruz Guitar Company, American manufacturer of acoustic guitars, Santa Cruz, California
• Santa Cruz Operation, software company
• Santa Cruz Skateboards, American brand of skateboards manufactured by NHS, Inc.
• Santa Cruz, sound card manufactured by Turtle Beach Systems

• Battle of Santa Cruz (disambiguation), list of notable battles bearing this name
• Battle of the Santa Cruz Islands, late−October, 1942
• Fort of Santa Cruz (Horta), fort in the Azores
• Fort of Santa Cruz (Oran), fort in Algeria

• Santa Cruz (band), a 2007–2024 Finnish hard rock band
• Santa Cruz, a 2024 album by Pedro the Lion
• "Santa Cruz (You're Not That Far)", a 2002 song by the Thrills

• Associação Atlética Santa Cruz, football club in Salinópolis
• Futebol Clube Santa Cruz, football club in Santa Cruz do Sol
• Santa Cruz Esporte Clube, football club in Barra do Bugres
• Santa Cruz Futebol Clube, football club in Recife
• Santa Cruz Futebol Clube (MG), football club in Belo Horizonte
• Santa Cruz Futebol Clube (RJ), football club in Rio de Janeiro
• Santa Cruz Futebol Clube (RN), football club in Natal
• Santa Cruz Recreativo Esporte Clube, football club in Santa Rita
• Sport Club Santa Cruz, football club in Santa Cruz, Rio Grande do Norte

• Deportes Santa Cruz, football club in Santa Cruz

• Real Santa Cruz, football club in Santa Cruz de la Sierra
• Club Blooming Santa Cruz, football club in Santa Cruz de la Sierra

• Santa Cruz Syndicate, professional mountain bike racing team
• Santa Cruz Warriors, basketball team
• UC Santa Cruz Banana Slugs, sports teams of the University of California, Santa Cruz

• Santa Cruz (Martian crater)
• Santa Cruz Cartel, Bolivian drug cartel
• Santa Cruz II, cruise ship of Ecuador
• Santa Cruz massacre, 1991 massacre in Timor-Leste (formerly Indonesia)
• Hyundai Santa Cruz, pickup truck introduced in 2021

• Canal de Santa Cruz, a salt water channel in the state of Pernambuco that separates the island of Itamaracá from the South American continent
• Cruz, a surname
• Cruz (disambiguation)
• Holy Cross (disambiguation) (English equivalent)
• Sainte-Croix (disambiguation) (French equivalent)
• Santa Croce (disambiguation) (Italian equivalent)
• Santa Cruise, a cruise ship that was previously named MS Annie Johnson
• Santa Cruz Canton (disambiguation)
• Santa Cruz District (disambiguation)
• Santa Cruz Formation (disambiguation)
• Santa Cruz Mountains, California
• Santa Cruz Province (disambiguation)
• St Cross (disambiguation)
• University of California, Santa Cruz, public research university