Samuel Moore may refer to:

• Samuel B. Moore (1789–1846), sixth Governor of Alabama
• Samuel M. Moore (1796–1875), U.S. Representative from Virginia
• Samuel Edward Moore (1803–1849), Western Australian politician
• Samuel Moore (colonial official) (1630–1688), New Jersey politician
• Samuel Moore (congressman) (1774–1861), U.S. Representative from Pennsylvania
• Samuel Wilkinson Moore (1854–1935), New South Wales Parliamentarian and Minister
• Sam Moore (Georgia politician) (born 1976), member of the Georgia House of Representatives
• Samuel Joseph Fortescue Moore, a member of the Western Australian Legislative Assembly in the early 1900s

• Sam Moore (gridiron football) (born 1964), American player of gridiron football
• Sammy Moore (born 1987), English footballer
• Sam Moore (rugby union) (born 1998), rugby union player
• Sam Moore (soccer) (born 2001), American soccer player

• Sam Moore (1935–2025), singer from the soul duo Sam & Dave
• Sam Moore (publisher) (1929–2018), CEO of Thomas Nelson
• Samuel P. Moore (1813–1889), U.S. Army doctor and Confederate Army surgeon general
• Samuel Preston Moore (1710–1785), American physician and public official
• Samuel N. Moore (1891–1942), U.S. Navy officer, namesake for the destroyer USS Samuel N. Moore
  • USS Samuel N. Moore
• Samuel Moore (Quaker leader) (1742–1821), early Quaker leader in Maritime Canada
• Samuel J. Moore (1859–1948), Canadian businessman, founder of Moore Business Forms
• Samuel Moore (translator) (1838–1911), translator of the 1887 English edition of Das Kapital

• Samuel More (1593–1662)
• Samuel More (1726–1799), apothecary
• Samuel More (MP), Member of Parliament (MP) for Shropshire